Amábille Petza Kloc, Fatima Anjum, Maximilian Wessner, Sarah Hudson, Philippe Fernandes, Bruno De Witte and Gabriele Sadowski*,
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PC-SAFT-Assisted Design of Antisolvent Naproxen Crystallization in the Presence of Polymers
The solubility of naproxen in aqueous solutions containing polyvinylpyrrolidone (PVP) or poly(vinylpyrrolidone-co-vinylacetate) (PVPVA64), was predicted using the thermodynamic model PC-SAFT. The predictions showed a lower solubility of naproxen in PVP solutions compared to PVPVA64 solutions, and the results were confirmed experimentally. Based on this data and their modeling, suitable process conditions for a solvent/antisolvent crystallization of naproxen in the presence of one of the two polymers were identified to produce long-acting injectable suspensions. Naproxen crystallization experiments were conducted by means of antisolvent precipitation from a supersaturated ethanol solution using water as antisolvent. PC-SAFT predictions were used to identify the initial naproxen concentration in solvent solutions, the optimum antisolvent-to-solvent stream ratio, the final naproxen loading, and the theoretical crystal yield, thus assisting the design of the crystallization experiments. The maximum absolute deviation between the experimental crystal yield and that obtained from PC-SAFT predictions was about 1.4%. The size of naproxen particles obtained from the crystallization experiments was less than 20 μm, which is in accordance with the particle size required for long-acting injectable suspensions.
期刊介绍：
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.
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