E.E.A. van Egmond , K. van der Hiele , M.J. de Rooij , D.A.M. van Gorp , P.J. Jongen , J.J.L. van der Klink , M.F. Reneman , E.A.C. Beenakker , J.J.J. van Eijk , S.T.F.M. Frequin , K. de Gans , E. Hoitsma , O.H.H. Gerlach , J.P. Mostert , W.I.M. Verhagen , L.H. Visser , H.A.M. Middelkoop
{"title":"复发缓解型多发性硬化症患者就业状况的纵向决定因素","authors":"E.E.A. van Egmond , K. van der Hiele , M.J. de Rooij , D.A.M. van Gorp , P.J. Jongen , J.J.L. van der Klink , M.F. Reneman , E.A.C. Beenakker , J.J.J. van Eijk , S.T.F.M. Frequin , K. de Gans , E. Hoitsma , O.H.H. Gerlach , J.P. Mostert , W.I.M. Verhagen , L.H. Visser , H.A.M. Middelkoop","doi":"10.1016/j.ibneur.2024.04.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS).</p></div><div><h3>Methods</h3><p>170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status.</p></div><div><h3>Results</h3><p>People with a deteriorated employment status after three years reported more depression (<em>p=</em>0.009), a higher impact of fatigue (<em>p<</em>0.001), more cognitive complaints (<em>p<</em>0.001) and less workplace support (<em>p=</em>0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status.</p></div><div><h3>Conclusion</h3><p>More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status.</p></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667242124000368/pdfft?md5=8315bfc67abd2fad550a0a94709ab5fd&pid=1-s2.0-S2667242124000368-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis\",\"authors\":\"E.E.A. van Egmond , K. van der Hiele , M.J. de Rooij , D.A.M. van Gorp , P.J. Jongen , J.J.L. van der Klink , M.F. Reneman , E.A.C. Beenakker , J.J.J. van Eijk , S.T.F.M. Frequin , K. de Gans , E. Hoitsma , O.H.H. Gerlach , J.P. Mostert , W.I.M. Verhagen , L.H. Visser , H.A.M. Middelkoop\",\"doi\":\"10.1016/j.ibneur.2024.04.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS).</p></div><div><h3>Methods</h3><p>170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status.</p></div><div><h3>Results</h3><p>People with a deteriorated employment status after three years reported more depression (<em>p=</em>0.009), a higher impact of fatigue (<em>p<</em>0.001), more cognitive complaints (<em>p<</em>0.001) and less workplace support (<em>p=</em>0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status.</p></div><div><h3>Conclusion</h3><p>More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status.</p></div>\",\"PeriodicalId\":13195,\"journal\":{\"name\":\"IBRO Neuroscience Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667242124000368/pdfft?md5=8315bfc67abd2fad550a0a94709ab5fd&pid=1-s2.0-S2667242124000368-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IBRO Neuroscience Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667242124000368\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IBRO Neuroscience Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667242124000368","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Longitudinal determinants of employment status in people with relapsing-remitting multiple sclerosis
Purpose
To investigate longitudinal relationships between employment status and disease-related, (neuro)psychological, and work-related factors in people with multiple sclerosis (MS).
Methods
170 employed people with MS underwent yearly neurological and neuropsychological examinations to assess MS-related disability and cognitive functioning. Additionally, they completed yearly questionnaires assessing depression, anxiety, fatigue, cognitive complaints, workplace support and coping. Multilevel models for change were fitted to examine progression of these factors over three years, and to assess possible relationships with change in employment status.
Results
People with a deteriorated employment status after three years reported more depression (p=0.009), a higher impact of fatigue (p<0.001), more cognitive complaints (p<0.001) and less workplace support (p=0.001) at baseline than people with a stable employment status. There were no differences in progression over time of the examined variables between people with a stable or deteriorated employment status.
Conclusion
More depression, a higher impact of fatigue, more cognitive complaints and less workplace support are predictive of a deteriorated employment status after three years in individuals with MS. How these factors progress over time is not different between those with a stable or deteriorated employment. MS-related disability, anxiety, objective cognition and coping were not related to a deterioration in employment status.
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