Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach

A series of six novel polyesters (P₁-P₆) were obtained via by direct polycondenzation with hydroxyl functional-appended chromone and curcumin based monomers (M₁, M₂ and M₃) were synthesized and subjected to thermogravimetric and spectroscopic analyses for structural characterization. The synthesized polymers were soluble common organic solvent such as DMF, THF, DMAc and 1-methyl-2-pyrrolidinone (NMP). The molecular weight of the polymers was found to be ranged from 3.390 × 10⁵ – 1.1 × 10⁵ g/mol by GPC-MALS. X-ray diffraction pattern of polyesters indicates P₁, P₂ and P₃ are amorphous in nature, whereas polymer P₄, P₅, and P₆ shows crystalline nature. The receptor VEGFR2 kinase can expand the synthesized molecules into 2D and 3D supramolecular networking through π-π stacking, hydrophobic, and H-bonding interactions. The cell viability effects of polymers on the growth of cell lines A549, HeLa and VERO were evaluated in vitro by MTT assay. The polymer P₃ displayed potent anticancer activity compared to the other polymers. Research is undergone in developing curcumin chromone functional polymer as a workable biopolymer which could find value in the present findings.