点燃火炬：预测尿路上皮癌免疫疗法反应的瘤内 T 细胞-间质富集评分

IF 81.1 1区医学 Q1 ONCOLOGY

Nature Reviews Clinical Oncology Pub Date : 2024-04-15 DOI:10.1038/s41571-024-00890-2

David H. Aggen, Jonathan E. Rosenberg

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引用次数: 0

摘要

肿瘤微环境（TME）中的 T 细胞浸润是持续抗肿瘤免疫反应的先决条件。然而，为临床应用确定量化 T 细胞浸润的预测性生物标记物以及与免疫检查点抑制剂 (ICI) 反应相关的促炎 TME 的存在已被证明具有挑战性。在此，我们重点介绍一项研究，该研究验证了从 RNA 测序数据中生成的 T 细胞-间质富集评分是尿路上皮癌患者 ICI 反应的新型生物标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lighting the torch: intratumoural T cell-to-stroma enrichment score as a predictor of immunotherapy response in urothelial carcinoma

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Lighting the torch: intratumoural T cell-to-stroma enrichment score as a predictor of immunotherapy response in urothelial carcinoma

T cell infiltration in the tumour microenvironment (TME) is a prerequisite for sustained antitumour immune responses. However, identifying predictive biomarkers that quantify T cell infiltration and the presence of proinflammatory TMEs associated with immune-checkpoint inhibitor (ICI) response for clinical implementation has proved challenging. Here, we highlight a study that validates a T cell-to-stroma enrichment score generated from RNA sequencing data as a novel biomarker for ICI response in patients with urothelial carcinoma.

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来源期刊

Nature Reviews Clinical Oncology 医学-肿瘤学

CiteScore

99.40

自引率

0.40%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.