成纤维细胞生长因子 6

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2024-04-10 DOI:10.1016/j.diff.2024.100780

Jennelle Smith , Loydie A. Jerome-Majewska

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引用次数: 0

摘要

成纤维细胞生长因子 6（FGF6），又称 HST2 或 HBGF6，是成纤维细胞生长因子（FGF）、肝素结合生长因子（HBGF）和肝素结合分泌转化基因（HST）家族的成员。FGF6 的基因组和蛋白质结构在不同物种中高度保守，在肌肉和肌肉祖细胞中的表达也是如此。与 FGF 家族的其他成员一样，FGF6 也能调节细胞的增殖、分化和迁移。具体来说，它在肌肉生成和肌肉再生、血管生成以及铁运输和脂质代谢中发挥着关键作用。与其他 FGF 家族成员类似，FGF6 也具有致癌转化活性，因此与多种癌症有关。

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Fibroblast Growth Factor 6

Fibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomic and protein structure of FGF6 is highly conserved among varied species, as is its expression in muscle and muscle progenitor cells. Like other members of the FGF family, FGF6 regulates cell proliferation, differentiation, and migration. Specifically, it plays key roles in myogenesis and muscular regeneration, angiogenesis, along with iron transport and lipid metabolism. Similar to others from the FGF family, FGF6 also possesses oncogenic transforming activity, and as such is implicated in a variety of cancers.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.