影响 ICR 小鼠繁殖性能的生物和环境因素

IF 1.6 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Toyohito Tanaka
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引用次数: 0

摘要

背景 由于本实验室用于 37 项生殖毒性研究的 ICR 小鼠的品系名称和饲养设施从 1990 年到 2022 年发生了变化,因此我们在对照小鼠中调查了影响生殖参数的生物和环境因素,以检验背景数据的有效性。 方法 在出生时[产后第 0 天(PND)]测量窝仔数和性别比,在产后第 0 天和哺乳期第 21 天测量后代体重。采用逐步回归作为解释变量选择策略,通过多元回归分析评估了生物和环境因素与繁殖参数之间的关系。将出生窝产仔数、次性别比(雄性率)、出生体重(克)和品系名称等生物因素,以及设施(房间)、温度/湿度和垫料等环境因素作为解释变量,将出生窝产仔数、次性别比(雄性率)、出生体重(克)和PND 21时后代存活指数(%)等繁殖参数作为响应变量。 结果 没有发现任何生物和环境因素对产仔数和性别比(雄性比例)有明显影响。雌雄后代体重受品系名称的影响很大。任何生物和环境因素都不会对 PND 21 时雌雄个体的存活率(%)产生明显影响。 结论 本报告中的窝产仔数和性别比例足以作为整个期间的背景数据,因为生物和环境因素对窝产仔数和性别组成没有明显影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological and environmental factors influencing reproductive performance in ICR mice, Mus musculus

Background

Since strain names and breeding facilities of ICR mice used in 37 reproductive toxicity studies have changed from 1990 to 2022 in our laboratory, biological and environmental factors that affect reproductive parameters were investigated in control mice to examine the validity of the background data.

Methods

Litter size and sex ratio were measured at birth [postnatal day (PND) 0], while offspring body weight was measured on PND 0 and 21 during the lactation. The relationships between biological and environmental factors and reproductive parameters were assessed with multiple regression analysis using stepwise regression as an explanatory variable selection strategy. The biological factors of litter size at birth, secondary sex ratio (male%), body weight (g) at birth and strain name, and environmental factors of facilities (room), temperature/humidity, and bedding materials were used as explanatory variables, and reproductive parameters of litter size at birth, secondary sex ratio (male%), body weight (g) at birth, and survival index (%) of offspring at PND 21 were used as response variables.

Results

No significant effects were indicated in litter size and sex ratio (male %) with any biological and environmental factors. Male and female offspring weights were significantly affected by strain names. No significant effects were indicated in the survival index (%) at PND 21 in both sexes with any biological and environmental factors.

Conclusions

Litter size and sex ratio in this report are sufficient as background data throughout the period because no significant variables of biological and environmental factors affected litter size and gender composition.

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来源期刊
Birth Defects Research
Birth Defects Research Medicine-Embryology
CiteScore
3.60
自引率
9.50%
发文量
153
期刊介绍: The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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