KHSO4 促进喹唑啉-4(3H)-酮和苯并噻二嗪 1,1-二氧化物的实用合成

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-04-04 DOI:10.1080/00397911.2024.2335638

Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan

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引用次数: 0

摘要

通过一种不含过渡金属的便捷方法，获得了范围广泛的喹唑啉-4(3H)-酮或苯并噻二嗪-1,1-二氧杂环。这种方法涉及 KHSO4，促进了多种官能化 2-氨基苯甲酰胺或 2-氨基苯磺酰胺与 N，N-二甲基甲酰胺衍生物之间的环化和脱水。该方案在温和的条件下，只需 6 小时的反应时间，就能获得中等到极好的产率（45%-93%）。使用环保且价格较低的催化剂 KHSO4 也使该方案更具吸引力。

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KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides

A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO₄ promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO₄ also makes this protocol more attractive.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.