使用连续葡萄糖监测指标和曲线比较 Equil 贴片与传统导管胰岛素泵在 2 型糖尿病患者中的应用

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yu-Jiao Li, Zi-Yue Shao, Yun-Qing Zhu, Da-Shuang Chen, Jian Zhu
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引用次数: 0

摘要

目的 目前尚不清楚 Equil 贴片和 MMT-712 胰岛素泵在血糖控制方面是否存在差异。我们的目的是利用连续血糖监测(CGM)指标和曲线,比较两种类型的胰岛素泵在治疗 2 型糖尿病(T2DM)方面的效果。 方法 这是一项随机病例交叉临床试验。参与者住院后随机分配到两组,接受两种类型的胰岛素泵治疗(A组:Equil贴片-美敦力MMT-712胰岛素泵;B组:美敦力MMT-712-Equil贴片胰岛素泵),中间间隔1天清洗期。胰岛素泵治疗 7-8 天后,血糖得到控制。每位患者连续 5 天(从第 1 天到第 5 天)接受 CGM。在进行 CGM 治疗的第 3 天,将 Equil 贴片胰岛素泵治疗转换为美敦力 MMT-712 胰岛素泵治疗,基础和栓注胰岛素剂量相同,反之亦然。CGM 指标和概况包括血糖变异性 (GV)、在量程内的时间 (TIR,3.9-10.0 mmol/L)、低于量程的时间 (TBR,<3.9 mmol/L)、高于量程的时间 (TAR,>10.0 mmol/L)、餐后血糖偏移以及低血糖发生率。 结果 46 名 T2DM 患者完成了研究。Equil 贴片胰岛素泵疗法与美敦力胰岛素泵疗法在每日血糖浓度和餐后血糖偏移参数上没有明显差异。同样,TIR、TBR 和 TAR 以及低血糖发生率也没有治疗间差异。 结论 在血糖控制方面,Equil 贴片胰岛素泵与传统的 MMT-712 胰岛素泵相似。Equil 贴片胰岛素泵是糖尿病血糖管理的可靠工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparing Equil patch versus traditional catheter insulin pump in type 2 diabetes using continuous glucose monitoring metrics and profiles

Comparing Equil patch versus traditional catheter insulin pump in type 2 diabetes using continuous glucose monitoring metrics and profiles

Aims

It is not clear whether there are differences in glycemic control between the Equil patch and the MMT-712 insulin pump. Our objective was to compare two types of insulin pumps in the treatment of type 2 diabetes mellitus (T2DM), using continuous glucose monitoring (CGM) metrics and profiles.

Methods

This was a randomized case-crossover clinical trial. Participants were hospitalized and randomly allocated to two groups and underwent two types of insulin pump treatments (group A: Equil patch—Medtronic MMT-712 insulin pump; group B: Medtronic MMT-712—Equil patch insulin pump) separated by a 1-day washout period. Glycemic control was achieved after 7–8 days of insulin pump therapy. Each patient received CGM for 5 consecutive days (from day 1 to day 5). On day 3 of CGM performance, the Equil patch insulin pump treatment was switched to Medtronic MMT-712 insulin pump treatment at the same basal and bolus insulin doses or vice versa. CGM metrics and profiles including glycemic variability (GV), time in range (TIR, 3.9–10.0 mmol/L), time below range (TBR, <3.9 mmol/L), time above range (TAR, >10.0 mmol/L), and postprandial glucose excursions, as well as incidence of hypoglycemia.

Results

Forty-six T2DM patients completed the study. There was no significant difference in parameters of daily GV and postprandial glucose excursions between the Equil patch insulin pump treatment and the Medtronic insulin pump treatment. Similarly, there was no between-treatment difference in TIR, TBR, and TAR, as well as the incidence of hypoglycemia.

Conclusion

The Equil patch insulin pump was similar to the traditional MMT-712 insulin pump in terms of glycemic control. Equil patch insulin pump is a reliable tool for glycemic management of diabetes mellitus.

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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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