临床研究参与者过少或过多的伦理问题

Q3 Medicine

Ethics, Medicine and Public Health Pub Date : 2024-01-01 DOI:10.1016/j.jemep.2024.100980

L.O. Rosengaard , S. Fonnes , J. Rosenberg

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引用次数: 0

摘要

背景在进行临床研究时，确保适当的样本量对伦理至关重要。讨论参与者人数不足可能导致研究动力不足，从而影响真正效果的检测，并使患者接受次优治疗。另一方面，过多的参与者也会引发伦理问题，使个人承受不必要的风险和负担，并造成研究浪费，如滥用资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ethical concerns of including too few or too many participants in clinical studies

Background

Ensuring an appropriate sample size is crucial for ethical reasons when conducting a clinical study.

Discussion

Insufficient participants may lead to underpowered studies, jeopardizing the detection of true effects and exposing individuals to suboptimal treatment. On the other hand, an excessive number of participants raise ethical concerns, subjecting individuals to unnecessary risks and burdens, and contributing to research waste, such as the misuse of resources.

Conclusion

Overall, there is a significant emphasis on striking a balance in participant inclusion to attain accurate, generalizable, and ethical outcomes in clinical trials.

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来源期刊

Ethics, Medicine and Public Health Medicine-Health Policy

CiteScore

2.20

自引率

0.00%

发文量

107

审稿时长

42 days

期刊介绍： This review aims to compare approaches to medical ethics and bioethics in two forms, Anglo-Saxon (Ethics, Medicine and Public Health) and French (Ethique, Médecine et Politiques Publiques). Thus, in their native languages, the authors will present research on the legitimacy of the practice and appreciation of the consequences of acts towards patients as compared to the limits acceptable by the community, as illustrated by the democratic debate.