COVID19 死亡率与 2021 年血液和细胞因子水平参数的相关性

Yusra Kadhim Ali Al-Saadi, Prof. Dr. Besma Bel Hadj Jrad
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摘要

COVID-19 疫情给全球医疗系统造成了巨大压力。有效的患者护理和公共卫生政策需要了解 COVID-19 的死亡率变量。本研究探讨了人口统计学、合并症、细胞因子参数和住院时间对 COVID-19 死亡率的影响。研究回顾性地检查了 2021 年的 100 名伊拉克 COVID-19 患者。研究人员使用 SPSS 和 Excel 分析了来自医疗城医院和 Al-Kadhimiya 医院的数据。研究参与者的年龄和性别各不相同。根据年龄、性别和合并症的不同,2021 年 COVID-19 的死亡率为 22%。在年龄小于 30 岁的人群中(9 人),22.2% 的人死于该疾病。在 31-40 岁年龄段(人数=24)中,25.0%的人死亡。41-50 岁年龄组(15 人)的死亡率为 40.0%。在 51-60 岁年龄组(人数=27)中,25.9% 的人死亡。61-70 岁年龄组(18 人)的死亡率为 5.6%。70 岁以上(7 人)无一死亡。患者的年龄(而非性别)与死亡率有显著相关性。在分析的参数中,铁蛋白、D-二聚体、淋巴细胞和中性粒细胞与淋巴细胞比值(NLR)水平在死亡组和存活组之间存在显著差异(P 值<0.05)。合并症分析表明,心血管疾病、恶性肿瘤、肾脏疾病和细菌感染与 COVID-19 患者较高的死亡率有显著相关性,而肝脏疾病、糖尿病(DM)和高血压(HT)则无显著相关性。死亡患者和存活患者的 IL6、IL10 和 IL12 细胞因子水平差异显著。这些白细胞介素水平升高与死亡风险增加有关,而TNF-a水平则无明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
COVID19 MORTALITY CORRELATION WITH THE BLOOD AND CYTOKINE LEVELS PARAMETERS IN 2021
The COVID-19 epidemic has strained healthcare systems globally. Effective patient care and public health policies need understanding COVID-19 mortality variables. This research examines how demographics, comorbidities, cytokine parameters, and hospitalization time affect COVID-19 mortality. The research retrospectively examined 100 Iraqi COVID-19 patients in 2021. Data from Medical City Hospital and Al-Kadhimiya Hospital were analyzed using SPSS and Excel. Study participants were of various ages and genders. The 2021 COVID-19 death rate was 22%, depending on age, gender, and comorbidities. Out of persons aged ≤30 (n=9), 22.2% died from the illness. In the 31-40 age range (n=24), 25.0% died. The 41-50 age group (n=15) had a 40.0% death rate. In the 51-60 age range (n=27), 25.9% died. The 61-70 age group (n=18) had a 5.6% death rate. No one over 70 (n=7) died. The age of patients, but not gender, are significantly associated with mortality. Among the parameters analyzed, ferritin, D-dimer, lymphocytes, and the neutrophil-to-lymphocyte ratio (NLR) levels showed significant differences between the deceased and alive groups (p-value <0.05). Comorbidity analysis demonstrated that cardiovascular diseases, malignancy, kidney diseases, and bacterial infections were significantly associated with higher mortality rates in COVID-19 patients, while liver disease, diabetes mellitus (DM), and hypertension (HT) did not show significant associations. IL6, IL10, and IL12 cytokines levels differed significantly between died and surviving patients. Elevated levels of these interleukins were associated with increased mortality risk, while TNF-a levels showed no significant difference.
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