122 例新生儿早期贫血的风险因素和心肌生物标志物水平变化分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.55730/1300-0144.5788

Zhenhua Sui

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引用次数: 0

摘要

背景/目的：出生后第一周的贫血可能会影响生长发育和器官功能，因此应成为临床医生的一个重要警示信号。本研究旨在评估新生儿早期贫血的相关风险因素，并分析贫血对新生儿心肌标志物表达水平的影响。材料和方法：收集 122 例确诊贫血新生儿和 108 例非贫血新生儿的临床数据，采用逻辑回归分析法分析早期贫血的独立风险因素。采集两组新生儿的血液样本，用于检测心肌标志物，包括蛋白标志物心肌钙蛋白 T（cTnT）以及酶标志物肌酸激酶同工酶 MB（CK-MB）和乳酸脱氢酶（LDH）。结果多变量逻辑回归分析显示，早产（OR：3.589 [1.119-11.506]，P <0.05）、多胎妊娠（OR：4.117 [1.021-16.611]，P <0.05）和异常胎盘（OR：4.712 [1.077-20.625]，P <0.05）是新生儿早期贫血的独立风险因素。心肌标志物水平，包括 cTnT（303.1 ± 244.7 vs. 44.2 ± 55.41 ng/L）、CK-MB（6.803 ± 8.971 vs. 2.5326 ± 2.927 µkat/L）和 LDH（32.42 ± 35.26 vs. 19.73 ± 17.13 µkat/L）、

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Analysis of risk factors and changes in myocardial biomarker levels in 122 cases of early neonatal anemia

Background/aim: Anemia in the first week after birth, which could affect growth, development, and organ function, should be an important warning sign to clinicians. The aim of this study was to assess the related risk factors of early neonatal anemia and to analyze the effect of anemia on the expression levels of myocardial markers in newborns. Materials and methods: Clinical data from 122 confirmed cases of anemic newborns and 108 nonanemic newborns were collected to analyze the independent risk factors for early anemia using logistic regression analyses. Blood samples were collected from both groups for the detection of myocardial markers, including the protein marker cardiac troponin T (cTnT), as well as enzyme markers creatine kinase isoenzyme MB (CK-MB) and lactate dehydrogenase (LDH). Results: Multivariate logistic regression analysis revealed that preterm birth (OR: 3.589 [1.119–11.506], p < 0.05), multiple pregnancy (OR: 4.117 [1.021–16.611], p < 0.05), and abnormal placenta (OR: 4.712 [1.077–20.625], p < 0.05) were independent risk factors for early neonatal anemia. The levels of myocardial markers, including cTnT (303.1 ± 244.7 vs. 44.2 ± 55.41 ng/L), CK-MB (6.803 ± 8.971 vs. 2.5326 ± 2.927 µkat/L), and LDH (32.42 ± 35.26 vs. 19.73 ± 17.13 µkat/L),

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.