Ahmed S. Ali, Marwa Ghazally, Mohamed Amir Fathy, Samia Atwa, Safwat M. Abdel-Aziz
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引用次数: 0
摘要
子痫前期(PE)是一种常见疾病,尤其是在发展中国家。子痫前期会影响母体的免疫细胞和细胞因子,使促炎症细胞因子增多,调节细胞减少。它对新生儿死亡率和发病率有短期和长期影响。本研究旨在概述以往讨论 PE 对婴儿免疫力影响的文献,以帮助设计未来的研究。我们在三个数据库(包括 PubMed、Medline 和 EMBASE)中使用网状词和文本词进行了全面检索。我们找到了从 2000 年到搜索期间发表的 851 篇论文。有 24 项研究符合纳入标准,并被纳入质量评估。24 项研究涉及 PE 对新生儿各种免疫细胞和细胞因子的影响。PE 与新生儿多种免疫细胞数量减少有关,尤其是中性粒细胞,中性粒细胞和自然杀伤(NK)细胞的细胞毒性作用增强。Treg细胞显著减少,而细胞毒性T细胞CD8+和记忆细胞CD45RO+(CD4+和CD8+)均有所增加。在重症 PE 中,IL6、IL8 和 TNF 等促炎细胞因子升高。PE 与新生儿调节性免疫细胞减少、免疫细胞的细胞毒性能力增强以及促炎细胞因子的流行有关。这些变化是在脐带血和外周血样本中观察到的;然而,未来的研究应调查 PE 对新生儿免疫力的长期影响。
Immune Changes in Infants of Preeclampsia Mothers: A Systematic Review of Literature
Preeclampsia (PE) is a prevalent disease especially in developing countries. PE influences maternal immune cells and cytokines, with prevailing of proinflammatory cytokines and reduction of regulatory cells. It has a short- and long-term impact on newborn mortalities and morbidities. The aim of this study is to provide an overview of previous literature discussing the effect of PE on infant immunity to help design future research. A comprehensive search was done on three databases including PubMed, Medline, and EMBASE with mesh and text terms. We could identify 851 titles published from 2000 to the time of search. Twenty-four studies met the inclusion criteria, and they were included in the quality assessment. Twenty-four studies were identified, covering the impact of PE on various neonatal immune cells and cytokines. PE is associated with a decrease in the number of several immune cells in newborns, particularly neutrophils, with enhancing cytotoxic effect of both neutrophils and natural killer (NK) cells. Treg cells were considerably reduced with increase of cytotoxic T cells CD8+ and memory cells CD45RO+ in both CD4+ and CD8 + . Proinflammatory cytokines like IL6, IL8, and TNF were raised in severe PE. PE is linked to a decrease in regulatory immune cells and an increase in the immune cells' cytotoxic capability, as well as the prevalence of proinflammatory cytokines in newborns. These changes were observed in cord blood and peripheral blood samples; however, future research should investigate the long-term effect of PE on neonatal immunity.