M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili
{"title":"biginelli 反应：果汁比较研究、优化策略、硅内分析和药理活性","authors":"M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili","doi":"10.38164/ajper/13.1.2024.50-65","DOIUrl":null,"url":null,"abstract":"This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC","PeriodicalId":8533,"journal":{"name":"Asian Journal of Pharmaceutical Education and Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"BIGINELLI REACTION: COMPARATIVE STUDY OF FRUIT JUICES, OPTIMIZATION STRATEGIES, IN-SILICO ANALYSIS AND PHARMACOLOGICAL ACTIVITY\",\"authors\":\"M. Hudgi, S. Santh, A. Awasthi, B. Mantripragada, D. Pingili\",\"doi\":\"10.38164/ajper/13.1.2024.50-65\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC\",\"PeriodicalId\":8533,\"journal\":{\"name\":\"Asian Journal of Pharmaceutical Education and Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Pharmaceutical Education and Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.38164/ajper/13.1.2024.50-65\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Pharmaceutical Education and Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.38164/ajper/13.1.2024.50-65","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
BIGINELLI REACTION: COMPARATIVE STUDY OF FRUIT JUICES, OPTIMIZATION STRATEGIES, IN-SILICO ANALYSIS AND PHARMACOLOGICAL ACTIVITY
This research article explores the influence of fruit juices on the efficiency of the biginelli reaction, a versatile multicomponent synthesis for diverse dihydropyrimidinones. A comparative analysis of fruit juices as green reaction media assessed their impact on reaction rates, yields, and selectivity. Biginelli reactions were carried out in fruit juices using equimolar mixture of thiourea /urea, ethyl acetoacetate and aromatic aldehyde under microwave irradiation. The reaction progressed within minutes, monitored by TLC
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