一名炎症性肠病患者的脓皮病

Y. Uspensky, Yu. A. Fominykh, O. A. Kizimova, A. Gnutov, E. Kalinina, E. P. Fedotova, R. A. Nasyrov, A. A. Kozobin, R. A. Guchapshev
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引用次数: 0

摘要

几乎所有器官和系统,包括眼睛、皮肤、肺、肾脏、肝脏以及造血器官和心血管系统都会受到损害,从而使炎症性肠病的病程复杂化。在这种情况下,皮肤病最常受到影响,10% 以上的炎症性肠病患者会出现皮肤肠外表现。在皮肤肠外表现中,发病率仅次于结节性红斑的是脓疱疮--嗜中性粒细胞皮肤病,这是一种特发性疾病,多与全身免疫炎症有关,如类风湿性关节炎、血细胞增多症或肠道疾病。此外,这种疾病也是由基因决定的综合征(如 PAPA、PASH、PAPASH 和 SAPHO)的组成部分之一。诊断和检测这种疾病的困难在于缺乏对这些患者的标准化诊治方法、随机试验结果的实现以及脓皮病药物治疗可靠性的鉴定。本文对文献进行了综述,作为临床表现,确定了对脓毒症并发炎症性肠病发病患者的观察结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pyoderma gangrenosum in a patient with onset of inflammatory bowel diseases
The course of inflammatory bowel diseases can be complicated by damage to almost all organs and systems, including the eyes, skin, lungs, kidneys, liver, as well as hematopoietic organs and the cardiovascular system. In this case, skin diseases are most often affected, and skin extraintestinal manifestations occur in more than 10% of patients with inflammatory bowel disease. Among the cutaneous extraintestinal manifestations, the second place in prevalence after erythema nodosum is occupied by pyoderma gangrenosum - neutrophilic dermatosis, an idiopathic disease, most often associated with systemic immune-inflammatory conditions, such as rheumatoid arthritis, hemoblastoses or intestinal diseases. Also, this disease is one of the components of such genetically determined syndromes as PAPA, PASH, PAPASH and SAPHO. Difficulties in diagnosing and detecting this condition are due to the lack of a standardized approach to the appointment of these patients, the achievement of the results of randomized trials, and the identification of the reliability of the reliability of drug therapy for pyoderma gangrenosum. This article presents a review of the literature and, as a clinical manifestation, an observation in patients with the onset of inflammatory bowel disease complicated by pyoderma gangrenosum was identified.
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