克什米尔一家三级医院重症监护室收治的药物滥用患者的临床概况和预后:前瞻性观察研究

Reyaz Ahmed Qadri, S. Sidiq, Majid Jehangir, A. H. Mir, Talib Khan, Abdul Waheed Mir, Majid Khan, MD Senior Resident Mbbs
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摘要

导言:药物滥用是一个全球性的公共卫生问题,给医疗保健系统,尤其是重症监护病房(ICU)带来了巨大挑战。本研究旨在评估印度北部一家三级医院重症监护室收治的药物滥用患者的临床概况和治疗效果:这项前瞻性观察研究为期 3 年,涉及重症监护室收治的药物滥用患者。研究记录了人口统计学数据、临床特征、药物滥用模式、并发症、严重程度评分和结果:研究共纳入 35 名患者。所有患者均为男性,平均年龄为 29.1(± 11.68)岁。42.8%的患者为失业者。大多数患者(85.7%)未婚。34.3%为学生。入住重症监护室时的平均 APACHE II 评分为 13 分。大多数患者因吸食海洛因过量入院(60%)。重症监护室收治的所有 35 名患者的格拉斯哥昏迷量表(GCS< 7)均较低。32 名患者(91.4%)伴有呼吸衰竭。7 名患者心血管不稳定。4名(11.4%)患者在重症监护室住院期间出现多器官功能衰竭。入住重症监护室的平均时间为 3.4 (± 2.68)。23(65.7%)名患者在入住重症监护室 24 小时内拔管。研究组中有 4 名患者死亡(死亡率为 11.4%)。一名患者死于败血症,3 名患者死于多器官功能衰竭:结论:大多数用药过量都是由于阿片类药物,尤其是海洛因。所有用药过量的患者都出现了中枢神经系统抑制,其次是呼吸衰竭。多器官受累的结果很差。11.4%的入院患者因败血症和多器官功能衰竭而死亡。大多数患者的预后良好,尤其是那些早期到医疗机构就诊的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Profile and Outcome of Drug Abuse Patients Admitted in Intensive Care Unit of a Tertiary Care Hospital in Kashmir: A Prospective Observational Study
Introduction: Drug abuse is a global public health issue that poses significant challenges to healthcare systems particularly in intensive care units (ICU). This study aims to assess the clinical profile and outcomes of drug abuse patients admitted to ICU of a tertiary care hospital in North India.Methods: A prospective observational study was conducted over period of 3 years involving drug abuse patients admitted to the ICU. Demographic data, clinical characteristics, substance abuse patterns, co-morbidities, severity scores and outcomes were recorded.Results: A total of 35 patients were included in the study. All patients were males with a mean age of 29.1(± 11.68).25 patients were from rural areas. 42.8% were unemployed. Most of the patients (85.7%) were unmarried. 34.3% were students. Mean APACHE II score on ICU admission was 13. Most of patients were admitted for heroin overdose (60%). All 35 patients admitted in ICU had low Glasgow coma scale (GCS< 7). 32 (91.4%) patients had associated respiratory failure. 7 patients had cardiovascular instability. 4 (11.4%) patients developed multi-organ failure during the ICU stay. Mean duration of ICU stay was 3.4 (± 2.68). 23 (65.7%) patients got extubated within 24 hours of ICU admission. 4 patients expired (11.4% mortality) in study group. Sepsis was cause of death in one patient, 3 patients died of multi-organ failureConclusion: Most of the overdose was due to opioids specifically of heroin. CNS depression was found in all drug overdose patients followed by respiratory failure. Multi organ involvement have poor outcome. Mortality ensued in 11.4% of admitted patients as a result of sepsis and multi-organ failure. Majority of the patients had good outcome especially patients who presented early to healthcare facility.
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