加强胃溃疡管理:特拉唑嗪-泮托拉唑联合疗法的新启示

Q4 Pharmacology, Toxicology and Pharmaceutics
Teresa J. Vadakutt, Gaurav M. Doshi
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引用次数: 0

摘要

在本研究中,我们通过研究α-1肾上腺素能受体抑制剂特拉唑嗪与常用抗溃疡药物泮托拉唑联用的治疗潜力,探索了一种治疗胃溃疡的新方法。研究采用乙醇诱导的大鼠胃溃疡模型,结果表明特拉唑嗪预处理能显著减少溃疡的形成,与单独使用泮托拉唑相比,特拉唑嗪-泮托拉唑联合用药能更好地保护粘膜。组织病理学分析表明,特拉唑嗪-泮托拉唑联合疗法保留了粘膜结构,减少了中性粒细胞浸润,显示出抗炎作用。在分子水平上,联合治疗组的磷酸甘油酸激酶 1(PGK-1)水平升高,这是细胞能量代谢的一种重要酶,而炎症标志物 IκB 激酶(IKK)和白细胞介素 6(IL-6)显著降低,表明炎症得到缓解。特拉唑嗪与泮托拉唑三种不同组合的研究结果表明,这可能是治疗胃溃疡的一种潜在方法,并有助于减少现有的泮托拉唑剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ENHANCING GASTRIC ULCER MANAGEMENT: NOVEL INSIGHTS FROM TERAZOSIN-PANTOPRAZOLE COMBINATION THERAPY
In this present study, we explored a novel approach to gastric ulcer management by investigating the therapeutic potential of terazosin, an alpha-1 adrenergic receptor inhibitor, in combination with pantoprazole, a common anti-ulcer agent. Employing an ethanol-induced rat-gastric ulcer model, the study demonstrated that terazosin pre-treatment significantly reduced ulcer formation, with the terazosinpantoprazole combination exhibiting superior mucosal protection compared to pantoprazole alone. Histopathological analysis revealed preserved mucosal structure and reduced neutrophil infiltration, indicating an anti-inflammatory effect. At a molecular level, the combination treatment groups exhibited elevated levels of phosphoglycerate kinase 1 (PGK-1), a vital enzyme in cellular energy metabolism, while inflammatory markers IκB kinase (IKK) and interleukin- 6 (IL-6) were significantly reduced, signifying mitigation of inflammation. These findings of the three different combinations of terazosin with pantoprazole indicate that this can be a potential approach for the treatment of gastric ulcers and can help in reducing the existing pantoprazole dose.
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来源期刊
INDIAN DRUGS
INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.30
自引率
0.00%
发文量
98
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