P16 在鉴别诊断分化良好的脂肪肉瘤和脂肪瘤中的诊断重要性

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-29 DOI:10.34172/ipp.2023.40558

P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat

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引用次数: 0

摘要

导言：由于病理重叠，很难将分化良好的脂肪肉瘤（WDL）与脂肪瘤区分开来。研究目的本研究旨在评估 P16 作为区分 WDL 和脂肪瘤的标志物的作用：本横断面研究于 2011 年至 2018 年期间在伊斯法罕医科大学附属扎赫拉医院病理科对 38 份脂肪瘤和 WDL 的病理样本进行了研究。研究样本通过免疫组化（IHC）检测P16的存在。结果显示IHC 数据评估显示，所有脂肪瘤样本（100%）的 IHC 染色得分均为 0。相比之下，84.2%的脂肪肉瘤样本的 IHC 得分为 3，这一差异具有统计学意义（P<0.001）。对 P16 基因表达的敏感性和特异性进行评估后发现，该标记物对脂肪肉瘤诊断的敏感性为 84%，特异性为 100%（95% CI：0.6042-0.9661）。结论使用P16来区分WDL和脂肪瘤的敏感性为84%，特异性为100%，这对病理实践很有帮助。

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Diagnostic importance of P16 in the differential diagnosis of well-differentiated liposarcoma and lipomas

Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.