P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat
{"title":"P16 在鉴别诊断分化良好的脂肪肉瘤和脂肪瘤中的诊断重要性","authors":"P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat","doi":"10.34172/ipp.2023.40558","DOIUrl":null,"url":null,"abstract":"Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"23 2","pages":""},"PeriodicalIF":16.4000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic importance of P16 in the differential diagnosis of well-differentiated liposarcoma and lipomas\",\"authors\":\"P. Hedayat, M. Derakhshan, Laya Golshani, Arash Hedayat\",\"doi\":\"10.34172/ipp.2023.40558\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":\"23 2\",\"pages\":\"\"},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/ipp.2023.40558\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/ipp.2023.40558","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Diagnostic importance of P16 in the differential diagnosis of well-differentiated liposarcoma and lipomas
Introduction: Because of pathological overlaps, distinguishing well-differentiated liposarcoma (WDL) from lipoma is difficult. Objectives: The purpose of this study was to evaluate P16 as a differentiating marker for WDL and lipomas Materials and Methods: This cross-sectional study was performed on 38 pathology samples of lipoma and WDL in the department of pathology of Al-Zahra hospital, affiliated with Isfahan university of medical sciences, from 2011 to 2018. The studied samples were examined by immunohistochemistry (IHC) to determine the presence of P16. Results: Evaluation of IHC data showed that all of the lipoma samples (100%) had a score of 0 for IHC staining. In comparison, 84.2% of liposarcoma samples had a score of 3, and this difference was statistically significant (P<0.001). Evaluating the sensitivity and specificity of P16 gene expression showed that this marker has 84% sensitivity and 100% specificity for diagnosing liposarcoma (95% CI: 0.6042-0.9661). Conclusion: The use of p16 to differentiate WDL from lipoma has a sensitivity of 84% and a specificity of 100%, which could be very helpful in pathological practice.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.