{"title":"保加利亚瓦尔纳女性乳腺癌免疫组化研究","authors":"Galina Yaneva, Ivan Maslarski","doi":"10.7546/crabs.2024.01.07","DOIUrl":null,"url":null,"abstract":"An immunohistochemical study of 128 female breast cancer patients in Varna is performed. The expression of estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2) and proliferation marker protein Ki-67 in terms of histological and molecular types and differentiation grade is assessed. Ductal carcinoma and luminal B HER2(+) prevail. The discrepancies between immunohistochemical positivity and negativity of single biomarkers are outlined.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Immunohistochemical Study of Female Breast Cancer in Varna, Bulgaria\",\"authors\":\"Galina Yaneva, Ivan Maslarski\",\"doi\":\"10.7546/crabs.2024.01.07\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An immunohistochemical study of 128 female breast cancer patients in Varna is performed. The expression of estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2) and proliferation marker protein Ki-67 in terms of histological and molecular types and differentiation grade is assessed. Ductal carcinoma and luminal B HER2(+) prevail. The discrepancies between immunohistochemical positivity and negativity of single biomarkers are outlined.\",\"PeriodicalId\":104760,\"journal\":{\"name\":\"Proceedings of the Bulgarian Academy of Sciences\",\"volume\":\"46 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Bulgarian Academy of Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7546/crabs.2024.01.07\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Bulgarian Academy of Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7546/crabs.2024.01.07","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
对瓦尔纳的 128 名女性乳腺癌患者进行了免疫组化研究。研究评估了雌激素和孕激素受体、人表皮生长因子受体 2 (HER2) 和增殖标记蛋白 Ki-67 在组织学和分子类型以及分化等级方面的表达情况。以乳腺管癌和管腔 B HER2（+）为主。概述了单一生物标记物的免疫组化阳性和阴性之间的差异。
Immunohistochemical Study of Female Breast Cancer in Varna, Bulgaria
An immunohistochemical study of 128 female breast cancer patients in Varna is performed. The expression of estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2) and proliferation marker protein Ki-67 in terms of histological and molecular types and differentiation grade is assessed. Ductal carcinoma and luminal B HER2(+) prevail. The discrepancies between immunohistochemical positivity and negativity of single biomarkers are outlined.
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