Shuang Xu, Xinyuan Li, Qing Hou, Ning Xu, Qingmiao Lu, Sudan Wang, Chunsun Dai
{"title":"血清不饱和脂肪酸模式与糖尿病肾病风险的关系","authors":"Shuang Xu, Xinyuan Li, Qing Hou, Ning Xu, Qingmiao Lu, Sudan Wang, Chunsun Dai","doi":"10.1159/000536532","DOIUrl":null,"url":null,"abstract":"Introduction: Unsaturated fatty acids play an essential role in the progression of diabetic nephropathy (DN). Previous studies were mainly focused on the role of individual unsaturated fatty acid. The serum unsaturated fatty acid patterns in patients with DN remains to be determined.\nMethods: A total of 135 patients with DN (DN group) and 322 patients with type II diabetes without nephropathy (non-DN group) were included in this study. Clinical data, serum levels of unsaturated fatty acids and other laboratory indicators were collected. Multivariate logistic regression was applied to identify risk factors for serum unsaturated fatty acids level in both groups. Serum unsaturated fatty acids were subjected to factor analysis to identify distinct fatty acid patterns (FAPs). Multivariable logistic regression was employed to assess the risk of DN associated with different serum FAPs. The role of FAPs major components was further validated at the cellular level.\nResults: After adjusting for confounders, three types of unsaturated fatty acid including C20:5 (eicosapentaenoic acid, EPA), C22:6 (docosahexaenoic, DHA) and C22:5 n-3 (docosapentaenoic acid, DPA n-3) were significantly associated with DN in the population. The odds ratios (ORs) (95% confidence interval [CI]) of DN were 0.583 (0.374, 0.908), 0.826 (0.716, 0.954) and 0.513 (0.298, 0.883), respectively. Factor analysis revealed five major FAPs, among of which, only FAP2 (enriched with EPA and DHA) exhibited a significant inverse association with DN. In the multivariate-adjusted model, the OR (95% CI) was 0.678 (0.493, 0.933). At the cellular level, DHA and EPA enriched in FAP2 reduced and a combination of which further decreased extracellular matrix production induced by transforming growth factor beta 1 (TGFβ1) in podocytes and tubular cells. \nConclusions: Our findings suggest that FAP2, enriched with DHA and EPA, is associated with a reduced risk of DN. This highlights the potential of targeting FAP2 for the patients with DN.\n","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of serum unsaturated fatty acid patterns with the risk of diabetic nephropathy\",\"authors\":\"Shuang Xu, Xinyuan Li, Qing Hou, Ning Xu, Qingmiao Lu, Sudan Wang, Chunsun Dai\",\"doi\":\"10.1159/000536532\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Unsaturated fatty acids play an essential role in the progression of diabetic nephropathy (DN). Previous studies were mainly focused on the role of individual unsaturated fatty acid. The serum unsaturated fatty acid patterns in patients with DN remains to be determined.\\nMethods: A total of 135 patients with DN (DN group) and 322 patients with type II diabetes without nephropathy (non-DN group) were included in this study. Clinical data, serum levels of unsaturated fatty acids and other laboratory indicators were collected. Multivariate logistic regression was applied to identify risk factors for serum unsaturated fatty acids level in both groups. Serum unsaturated fatty acids were subjected to factor analysis to identify distinct fatty acid patterns (FAPs). Multivariable logistic regression was employed to assess the risk of DN associated with different serum FAPs. The role of FAPs major components was further validated at the cellular level.\\nResults: After adjusting for confounders, three types of unsaturated fatty acid including C20:5 (eicosapentaenoic acid, EPA), C22:6 (docosahexaenoic, DHA) and C22:5 n-3 (docosapentaenoic acid, DPA n-3) were significantly associated with DN in the population. The odds ratios (ORs) (95% confidence interval [CI]) of DN were 0.583 (0.374, 0.908), 0.826 (0.716, 0.954) and 0.513 (0.298, 0.883), respectively. Factor analysis revealed five major FAPs, among of which, only FAP2 (enriched with EPA and DHA) exhibited a significant inverse association with DN. In the multivariate-adjusted model, the OR (95% CI) was 0.678 (0.493, 0.933). At the cellular level, DHA and EPA enriched in FAP2 reduced and a combination of which further decreased extracellular matrix production induced by transforming growth factor beta 1 (TGFβ1) in podocytes and tubular cells. \\nConclusions: Our findings suggest that FAP2, enriched with DHA and EPA, is associated with a reduced risk of DN. This highlights the potential of targeting FAP2 for the patients with DN.\\n\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-01-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000536532\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000536532","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Association of serum unsaturated fatty acid patterns with the risk of diabetic nephropathy
Introduction: Unsaturated fatty acids play an essential role in the progression of diabetic nephropathy (DN). Previous studies were mainly focused on the role of individual unsaturated fatty acid. The serum unsaturated fatty acid patterns in patients with DN remains to be determined.
Methods: A total of 135 patients with DN (DN group) and 322 patients with type II diabetes without nephropathy (non-DN group) were included in this study. Clinical data, serum levels of unsaturated fatty acids and other laboratory indicators were collected. Multivariate logistic regression was applied to identify risk factors for serum unsaturated fatty acids level in both groups. Serum unsaturated fatty acids were subjected to factor analysis to identify distinct fatty acid patterns (FAPs). Multivariable logistic regression was employed to assess the risk of DN associated with different serum FAPs. The role of FAPs major components was further validated at the cellular level.
Results: After adjusting for confounders, three types of unsaturated fatty acid including C20:5 (eicosapentaenoic acid, EPA), C22:6 (docosahexaenoic, DHA) and C22:5 n-3 (docosapentaenoic acid, DPA n-3) were significantly associated with DN in the population. The odds ratios (ORs) (95% confidence interval [CI]) of DN were 0.583 (0.374, 0.908), 0.826 (0.716, 0.954) and 0.513 (0.298, 0.883), respectively. Factor analysis revealed five major FAPs, among of which, only FAP2 (enriched with EPA and DHA) exhibited a significant inverse association with DN. In the multivariate-adjusted model, the OR (95% CI) was 0.678 (0.493, 0.933). At the cellular level, DHA and EPA enriched in FAP2 reduced and a combination of which further decreased extracellular matrix production induced by transforming growth factor beta 1 (TGFβ1) in podocytes and tubular cells.
Conclusions: Our findings suggest that FAP2, enriched with DHA and EPA, is associated with a reduced risk of DN. This highlights the potential of targeting FAP2 for the patients with DN.
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