超低剂量的微ARN能使慢性活动性爱泼斯坦-巴氏病毒感染（CAEBV）患者恢复强大的免疫反应

International Journal of Scholarly Research and Reviews Pub Date : 2024-01-30 DOI:10.56781/ijsrr.2024.4.1.0071

Narges Bahi-Jaber, Gilbert Glady

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引用次数: 0

摘要

慢性活动性爱泼斯坦-巴氏病毒感染（CAEBV）是免疫系统对 EBV 感染的一种异常反应，其特点是缺乏抗 EBNA（EBV 核抗原）IgG，并与慢性疲劳和多种免疫相关疾病有关。我们在此介绍一种创新的 CAEBV 治疗方法，该方法基于使用超低剂量的参与宿主-病毒相互作用的非编码 RNA（ncRNA）。我们对使用我们的疗法治疗的 26 名患者进行了回顾性研究。所有患者均在开始治疗后的 18 个月内出现 EBNA IgG 阳性。在 25 例血清转换病例中，75% 的患者表示症状明显改善，尤其是慢性疲劳症状。这项研究证明，超低剂量的 ncRNAs 能有效恢复对 EBV 的免疫反应。更广泛地说，这种治疗方法可用于几乎所有病症。

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Ultra-low doses of microARNs restore a strong immune response in patients with Chronic Active Epstein-Barr Virus infection (CAEBV)

Chronic active Epstein-Barr Virus infection (CAEBV) is an abnormal response of the immune system to EBV infection, characterized by the absence of anti-EBNA (EBV Nuclear Antigens) IgG and associated with chronic fatigue and several immune related diseases. We present here an innovative therapeutic approach of CAEBV based on the use of ultra-low doses of non-coding RNAs (ncRNAs) involved in the host-virus interaction. We performed a retrospective study on 26 patients treated with our remedy. All the patients expect one developed positive EBNA IgG within eighteen months of starting treatment. Among the 25 cases that seroconverted, 75% report a significant improvement of their symptoms, especial of chronic fatigue. This study gives the proof of the efficiency of ultra-low doses of ncRNAs in restoring a strong immune response against EBV. More generally, this therapeutic approach can potentially be used in almost all pathologies.

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International Journal of Scholarly Research and Reviews

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