{"title":"基于胶原蛋白的电纺纳米纤维用于增强护肤成分输送的临床研究","authors":"Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra","doi":"10.3390/cosmetics11010018","DOIUrl":null,"url":null,"abstract":"Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":"182 5","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients\",\"authors\":\"Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra\",\"doi\":\"10.3390/cosmetics11010018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":\"182 5\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/cosmetics11010018\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/cosmetics11010018","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients
Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.
期刊介绍:
ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric.
Indexed/Abstracted:
Web of Science SCIE
Scopus
CAS
INSPEC
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