基于胶原蛋白的电纺纳米纤维用于增强护肤成分输送的临床研究

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra
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引用次数: 0

摘要

纳米纤维材料因其独特的性能,在包括化妆品在内的多个应用领域引起了广泛关注。胶原蛋白是人体皮肤的主要结构蛋白,在保持皮肤健康、弹性和促进皮肤再生方面发挥着重要作用,因而备受关注。本研究报告了用于护肤应用的新型胶原蛋白纳米纤维平台 DermaLayr™ 的特性、安全性和功效评估。胶原蛋白纳米纤维采用声波电纺丝技术开发而成,扫描电子显微镜(SEM)分析表明,纳米纤维均匀一致,平均纤维直径在 250 到 300 nm 之间。对 EpiDerm™ 进行的皮肤渗透研究表明,与未经处理的样品相比,使用测试产品可使表皮层的胶原蛋白渗透率提高约 5-25%,真皮层的胶原蛋白渗透率提高约 16-20%。此外,还对所开发纳米纤维的安全性进行了体外和体内评估,这两项研究都表明纳米纤维具有无毒、无刺激的特性。此外,对人体进行的临床试验进一步证实了 DermaLayr™ 的临床疗效,表明它能显著改善皮肤的多项参数,如水合作用、弹性和整体皮肤健康。总之,本研究的结果强调了 DermaLayr™ 纳米纤维产品在化妆品和皮肤治疗中安全应用的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients
Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
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