Seyyed Mohammad Matin Alavi Dana , Mohammadreza Meghdadi , Saeed Khayat Kakhki , Reza Khademi
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Current therapeutic approaches are expensive and have side effects.</p></div><div><h3>Objective</h3><p>In this investigation, we reviewed studies that investigated the anticancer effects of ginsenoside derivatives against leukemia and also explained the three main Ginsenoside derivatives (ginsenoside Rg3, Rh2, and Rg1) separately.</p></div><div><h3>Methods</h3><p>An extensive search was conducted in Pubmed, Web of Science, and Google Scholar and relevant studies that investigated anticancer effects of ginsenoside derivatives against leukemia cancer were extracted and reviewed.</p></div><div><h3>Results</h3><p>Preclinical studies reported that ginsenoside derivatives can induce apoptosis, suppress the proliferation of cancer cells, and induce differentiation and cell cycle arrest in leukemia cells. in addition, it can suppress the chemokine activity and extramedullary infiltration of leukemia cells from bone marrow. using herbal medicine and its derivatives is a promising approach to current health problems.</p></div><div><h3>Conclusion</h3><p>This review shows that ginsenoside derivatives can potentially suppress the growth of leukemia cells via various pathways and can be applied as a new natural medicine for future clinical research.</p></div>","PeriodicalId":10920,"journal":{"name":"Current Therapeutic Research-clinical and Experimental","volume":"100 ","pages":"Article 100739"},"PeriodicalIF":1.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0011393X24000092/pdfft?md5=698bcf91b99aae7f70c8b2cf7acb6237&pid=1-s2.0-S0011393X24000092-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Anti-leukemia effects of ginsenoside monomer: A narrative review of pharmacodynamics study\",\"authors\":\"Seyyed Mohammad Matin Alavi Dana , Mohammadreza Meghdadi , Saeed Khayat Kakhki , Reza Khademi\",\"doi\":\"10.1016/j.curtheres.2024.100739\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Leukemia is a prevalent disease with high mortality and morbidity rates. 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引用次数: 0
摘要
背景白血病是一种死亡率和发病率都很高的流行病。方法在 Pubmed、Web of Science 和 Google Scholar 上进行了广泛的搜索，提取并综述了研究人参皂苷衍生物对白血病癌症抗癌作用的相关研究。结果临床研究表明，人参皂苷衍生物能诱导癌细胞凋亡、抑制癌细胞增殖、诱导白血病细胞分化和细胞周期停滞，此外，它还能抑制趋化因子活性和骨髓中白血病细胞的髓外浸润。本综述表明，人参皂苷衍生物可通过多种途径抑制白血病细胞的生长，可作为一种新的天然药物应用于未来的临床研究。
Anti-leukemia effects of ginsenoside monomer: A narrative review of pharmacodynamics study
Background
Leukemia is a prevalent disease with high mortality and morbidity rates. Current therapeutic approaches are expensive and have side effects.
Objective
In this investigation, we reviewed studies that investigated the anticancer effects of ginsenoside derivatives against leukemia and also explained the three main Ginsenoside derivatives (ginsenoside Rg3, Rh2, and Rg1) separately.
Methods
An extensive search was conducted in Pubmed, Web of Science, and Google Scholar and relevant studies that investigated anticancer effects of ginsenoside derivatives against leukemia cancer were extracted and reviewed.
Results
Preclinical studies reported that ginsenoside derivatives can induce apoptosis, suppress the proliferation of cancer cells, and induce differentiation and cell cycle arrest in leukemia cells. in addition, it can suppress the chemokine activity and extramedullary infiltration of leukemia cells from bone marrow. using herbal medicine and its derivatives is a promising approach to current health problems.
Conclusion
This review shows that ginsenoside derivatives can potentially suppress the growth of leukemia cells via various pathways and can be applied as a new natural medicine for future clinical research.
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