全面分析叉头盒 J3 (FOXJ3) 在人类癌症中的作用

Q3 Multidisciplinary

Wuhan University Journal of Natural Sciences Pub Date : 2024-02-01 DOI:10.1051/wujns/2024291074

Yang Yang, Yulong Li, Xiao-Li Wang

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引用次数: 0

摘要

叉头盒 J3（FOXJ3）是叉头盒（Fox）家族的成员。最近，越来越多的证据揭示了 Fox 家族成员与癌症之间的关系。FOXJ3 参与了多种类型的癌症，包括肺癌、舌鳞癌和前列腺癌。在此，我们利用在线网站和数据库（包括 TIMER2.0、SangerBox、UALCAN、GEPIA2.0、cBioPortal、CancerSEA、STRING、BioGRID 和 Metascape）探索了 FOXJ3 在各种癌症中的功能，以分析 FOXJ3 在癌症中的作用。研究发现，FOXJ3在多种肿瘤中均有异常表达。结果发现，在脑低级胶质瘤（LGG）、肝肝细胞癌（LIHC）、肉瘤（SARC）和甲状腺癌中，FOXJ3表达升高与总生存率降低有关。在肾上腺皮质癌、LGG和LIHC中，FOXJ3表达升高与预后较差和无病生存有关。在几种癌症中，FOXJ3的表达与免疫浸润有关。富集分析表明，组蛋白修饰、TGF-β信号通路和染色质组织是FOXJ3前100个相似基因的前三个富集本体集群。我们的泛癌症分析从生物信息学的角度全面揭示了FOXJ3在不同癌症中的作用，它是预后的潜在生物标志物，尤其是在LGG和LIHC中。FOXJ3 还与某些人类肿瘤中的免疫浸润相关。

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Comprehensive Analysis of the Role of Forkhead Box J3 (FOXJ3) in Human Cancers

Forkhead box J3 (FOXJ3) is a member of the forkhead box (Fox) family. Recently, increasing evidence has revealed the relationship between Fox family members and cancer. FOXJ3 is involved in various types of cancer, including lung cancer, tongue squamous carcinoma, and prostate cancer; however, a comprehensive pan-cancer analysis of FOXJ3 remains lacking. Here, we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0, SangerBox, UALCAN, GEPIA2.0, cBioPortal, CancerSEA,STRING, BioGRID and Metascape to analyze the role of FOXJ3 in cancers. Abnormal expression of FOXJ3 was found in various tumors. The genetic alteration percentage in tumors was determined, and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG), liver hepatocellular carcinoma (LIHC), sarcoma (SARC) and thyroid carcinoma. Elevated FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma, LGG and LIHC. FOXJ3 expression was related to immune infiltration in several cancers. Enrichment analysis showed that histone modification, the TGF-β signaling pathway, and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of FOXJ3. Our pan-cancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers, where it serves as a potential biomarker for prognosis, especially in LGG and LIHC. FOXJ3 is also correlated with immune infiltrates in certain human tumors.

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来源期刊

Wuhan University Journal of Natural Sciences Multidisciplinary-Multidisciplinary

CiteScore

0.40

自引率

0.00%

发文量

2485

期刊介绍： Wuhan University Journal of Natural Sciences aims to promote rapid communication and exchange between the World and Wuhan University, as well as other Chinese universities and academic institutions. It mainly reflects the latest advances being made in many disciplines of scientific research in Chinese universities and academic institutions. The journal also publishes papers presented at conferences in China and abroad. The multi-disciplinary nature of Wuhan University Journal of Natural Sciences is apparent in the wide range of articles from leading Chinese scholars. This journal also aims to introduce Chinese academic achievements to the world community, by demonstrating the significance of Chinese scientific investigations.