{"title":"CFCN:基于泰勒扩展理论和多视角学习的 HLA 肽预测模型","authors":"B. Rao, Bing Han, Leyi Wei, Zeyu Zhang, Xinbo Jiang, Balachandran Manavalan","doi":"10.2174/0115748936299044240202100019","DOIUrl":null,"url":null,"abstract":"\n\nWith the increasing development of biotechnology, many cancer solutions\nhave been proposed nowadays. In recent years, Neo-peptides-based methods have made significant\ncontributions, with an essential prerequisite of bindings between peptides and HLA molecules.\nHowever, the binding is hard to predict, and the accuracy is expected to improve further.\n\n\n\nTherefore, we propose the Crossed Feature Correction Network (CFCN) with deep\nlearning method, which can automatically extract and adaptively learn the discriminative features\nin HLA-peptide binding, in order to make more accurate predictions on HLA-peptide binding\ntasks. With the fancy structure of encoding and feature extracting process for peptides, as well as\nthe feature fusion process between fine-grained and coarse-grained level, it shows many advantages\non given tasks.\n\n\n\nThe experiment illustrates that CFCN achieves better performances overall, compared\nwith other fancy models in many aspects.\n\n\n\nIn addition, we also consider to use multi-view learning methods for the feature fusion\nprocess, in order to find out further relations among binding features. Eventually, we encapsulate\nour model as a useful tool for further research on binding tasks.\n","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"420 1","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CFCN: An HLA-peptide Prediction Model based on Taylor Extension\\nTheory and Multi-view Learning\",\"authors\":\"B. Rao, Bing Han, Leyi Wei, Zeyu Zhang, Xinbo Jiang, Balachandran Manavalan\",\"doi\":\"10.2174/0115748936299044240202100019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nWith the increasing development of biotechnology, many cancer solutions\\nhave been proposed nowadays. In recent years, Neo-peptides-based methods have made significant\\ncontributions, with an essential prerequisite of bindings between peptides and HLA molecules.\\nHowever, the binding is hard to predict, and the accuracy is expected to improve further.\\n\\n\\n\\nTherefore, we propose the Crossed Feature Correction Network (CFCN) with deep\\nlearning method, which can automatically extract and adaptively learn the discriminative features\\nin HLA-peptide binding, in order to make more accurate predictions on HLA-peptide binding\\ntasks. With the fancy structure of encoding and feature extracting process for peptides, as well as\\nthe feature fusion process between fine-grained and coarse-grained level, it shows many advantages\\non given tasks.\\n\\n\\n\\nThe experiment illustrates that CFCN achieves better performances overall, compared\\nwith other fancy models in many aspects.\\n\\n\\n\\nIn addition, we also consider to use multi-view learning methods for the feature fusion\\nprocess, in order to find out further relations among binding features. Eventually, we encapsulate\\nour model as a useful tool for further research on binding tasks.\\n\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\"420 1\",\"pages\":\"\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-02-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.2174/0115748936299044240202100019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2174/0115748936299044240202100019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
CFCN: An HLA-peptide Prediction Model based on Taylor Extension
Theory and Multi-view Learning
With the increasing development of biotechnology, many cancer solutions
have been proposed nowadays. In recent years, Neo-peptides-based methods have made significant
contributions, with an essential prerequisite of bindings between peptides and HLA molecules.
However, the binding is hard to predict, and the accuracy is expected to improve further.
Therefore, we propose the Crossed Feature Correction Network (CFCN) with deep
learning method, which can automatically extract and adaptively learn the discriminative features
in HLA-peptide binding, in order to make more accurate predictions on HLA-peptide binding
tasks. With the fancy structure of encoding and feature extracting process for peptides, as well as
the feature fusion process between fine-grained and coarse-grained level, it shows many advantages
on given tasks.
The experiment illustrates that CFCN achieves better performances overall, compared
with other fancy models in many aspects.
In addition, we also consider to use multi-view learning methods for the feature fusion
process, in order to find out further relations among binding features. Eventually, we encapsulate
our model as a useful tool for further research on binding tasks.
期刊介绍:
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.