Yamato Nakamura, Masanori Sawamura, Tatsuhiko Miyazaki, Aya Muramatsu, Makoto Suzuki, Hiroaki Yagi, Akinobu Hori, Yusuke Katsuyama, Hidefumi Yoshida, Kang Kim, Hiroshi Yamada, Ryosuke Takahashi, K. Harada
{"title":"尽管使用了依库珠单抗和贝前列素，德戈斯病的神经症状仍在恶化：附详细放射学检查结果的病例报告","authors":"Yamato Nakamura, Masanori Sawamura, Tatsuhiko Miyazaki, Aya Muramatsu, Makoto Suzuki, Hiroaki Yagi, Akinobu Hori, Yusuke Katsuyama, Hidefumi Yoshida, Kang Kim, Hiroshi Yamada, Ryosuke Takahashi, K. Harada","doi":"10.1111/ncn3.12801","DOIUrl":null,"url":null,"abstract":"Degos disease is a rare vasculopathy with a poor prognosis. Here, we report a case of a 17‐year‐old Japanese male with Degos disease who exhibited progressive deterioration of neurological symptoms despite treatment with eculizumab and beraprost. We also report detailed radiological findings including brain magnetic resonance imaging and perfusion computed tomography, and hereby suggest the importance of the perfusion study in detecting early changes associated with Degos disease.","PeriodicalId":19154,"journal":{"name":"Neurology and Clinical Neuroscience","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deteriorating neurological symptoms of Degos disease despite the treatment with eculizumab and beraprost: A case report with detailed radiological findings\",\"authors\":\"Yamato Nakamura, Masanori Sawamura, Tatsuhiko Miyazaki, Aya Muramatsu, Makoto Suzuki, Hiroaki Yagi, Akinobu Hori, Yusuke Katsuyama, Hidefumi Yoshida, Kang Kim, Hiroshi Yamada, Ryosuke Takahashi, K. Harada\",\"doi\":\"10.1111/ncn3.12801\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Degos disease is a rare vasculopathy with a poor prognosis. Here, we report a case of a 17‐year‐old Japanese male with Degos disease who exhibited progressive deterioration of neurological symptoms despite treatment with eculizumab and beraprost. We also report detailed radiological findings including brain magnetic resonance imaging and perfusion computed tomography, and hereby suggest the importance of the perfusion study in detecting early changes associated with Degos disease.\",\"PeriodicalId\":19154,\"journal\":{\"name\":\"Neurology and Clinical Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2024-02-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurology and Clinical Neuroscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/ncn3.12801\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurology and Clinical Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/ncn3.12801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Deteriorating neurological symptoms of Degos disease despite the treatment with eculizumab and beraprost: A case report with detailed radiological findings
Degos disease is a rare vasculopathy with a poor prognosis. Here, we report a case of a 17‐year‐old Japanese male with Degos disease who exhibited progressive deterioration of neurological symptoms despite treatment with eculizumab and beraprost. We also report detailed radiological findings including brain magnetic resonance imaging and perfusion computed tomography, and hereby suggest the importance of the perfusion study in detecting early changes associated with Degos disease.
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