Hoang Le Tuan Anh, Ngo Viet Duc, Pham Van Cong, Ngo Van Hieu, Nguyen Van Dan, Vu Thi Trang, Do Thi Thu Hien, D. T. Tuan, Le Tuan Anh, Jeong Ah Kim
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引用次数: 0
摘要
从越南栽培的三七芽中分离出 8 种化合物，包括 20(R)- 人参皂苷 Rg3 (1)、人参皂苷 Rd (2)、人参皂苷 Rg2 (3)、人参皂苷 Re (4)、β-谷甾醇 (5)、龙葵甾醇 (6)、豆甾醇 (7) 和豆甾醇-3-O-β-葡萄糖苷 (8)。通过 1H、13C NMR 和 MS 光谱技术阐明了它们的结构，并与之前发表的文章进行了比较。此外，还评估了它们对 NO 生成的抑制活性以及对人类胚胎肾细胞（HEK-293A）和人类肝细胞癌（HepG2）的细胞毒性作用。这是首次对越南栽培的人参芽进行植物化学研究，人参芽也含有与 4-6 年根相同的主要活性人参皂甙。
Chemical constituents of Panax ginseng sprouts cultivated in Vietnam
Eight compounds, including 20(R)‐ginsenoside Rg3 (1), Ginsenoside Rd (2), ginsenosides Rg2 (3), ginsenosides Re (4), β‐sitosterol (5), daucosterol (6), stigmasterol (7), and stigmasterol‐3‐O‐β‐glucoside (8) were isolated from the Panax ginseng sprouts cultivated in Vietnam. Their structures were elucidated by 1H, 13C NMR, and MS spectroscopic techniques and compared with the previous publication. In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK‐293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6‐year old roots.
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