津巴布韦宫颈癌妇女的 GSTP、GSTT1、XRCC1 和 CASP8 基因变异与人类乳头瘤病毒的关系

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2024-02-26 DOI:10.2217/fvl-2023-0154

Oppah Kuguyo, Racheal S Dube Mandishora, N. Soko, Takudzwa Magwaku, A. Matimba, C. Dandara

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引用次数: 0

摘要

目的：研究宿主基因变异在高危人乳头瘤病毒（HR-HPVs）中的作用。研究方法这项横断面研究招募了 238 名宫颈癌患者。对转运（ABCC2）、异生物代谢（GSTP、GSTT1、GSTM1、NQO1）、DNA 修复（ERCC1、XRCC1）、免疫反应（TLR4）和细胞凋亡（CASP8、FASL、p53）基因的变异进行了鉴定。对肿瘤 DNA 进行了 14 种 HR-HPV 基因分型。结果显示GSTP rs1695GG、XRCC1 rs1799782TT 和 GSTT1 del/del 分别与 HPV51（几率比 [OR]：3.9；95% 置信区间 [CI]：1.3-11.7；p = 0.02）和 HPV58（OR：2.4；95% CI：1.2-5.8；p = 0.048）相关。CASP8 rs3834129del/del 与 HPV16/18（OR：2.7；95% CI：1.2-6.0；p = 0.017）和 HPV 单感染（OR：2.3；95% CI：1.2-4.4；p = 0.008）相关。结论GSTP、GSTT1、XRCC1 和 CASP8 变体与 HPV 阳性有关。通过进一步研究，可以开发出一种基于基因的筛查工具，与 HPV 疫苗一起用于预防宫颈癌。

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GSTP, GSTT1, XRCC1 and CASP8 genetic variations are associated with human papillomavirus in women with cervical cancer from Zimbabwe

Aim: Investigate the role of host genetic variations in high-risk human papillomaviruses (HR-HPVs). Methods: This cross-sectional study recruited 238 cervical cancer patients. Variants in transport (ABCC2), xenobiotic metabolism ( GSTP, GSTT1, GSTM1, NQO1), DNA repair ( ERCC1, XRCC1), immune response ( TLR4) and apoptosis ( CASP8, FASL, p53) genes were characterized. Tumor DNA was genotyped for 14 HR-HPVs. Results: GSTP rs1695GG, XRCC1 rs1799782TT and GSTT1 del/del were associated with HPV51 (odds ratio [OR]: 3.9; 95% confidence interval [CI]: 1.3–11.7; p = 0.02) and HPV58 (OR: 2.4; 95% CI: 1.2–5.8; p = 0.048), respectively. CASP8 rs3834129del/del was associated with HPV16/18 (OR: 2.7; 95% CI: 1.2–6.0; p = 0.017) and HPV monoinfections (OR: 2.3; 95% CI: 1.2–4.4; p = 0.008). Conclusion: GSTP, GSTT1, XRCC1 and CASP8 variants were associated with HPV-positivity. With further research, a genetic-based screening tool can be developed, to use with HPV vaccines toward preventing cervical cancer.

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.