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引用次数: 0
摘要
硫酰胺类抗甲状腺药物的发现，主要源于 20 世纪 40 年代不同研究人员的观察，他们发现含巯基的物质对动物有致甲状腺肿作用。Edwin B. Astwood 教授开始使用这些药物治疗甲状腺功能亢进症。在本文中，我们总结了这些药物的发展背景、2-硫脲嘧啶及其衍生物的配位可能性，以及其中一些复合物的生物活性。其中一些可用作治疗结核病和关节炎的药物，另一些具有杀菌和杀真菌活性，第三种具有细胞毒性，可用于治疗各种癌症。
Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review
The thionamide antithyroid agents were discovered largely through observations carried out by various researchers in the 1940s that found that sulfhydryl-containing substances were goitrogenic in animals. Prof. Edwin B. Astwood started using these drugs to treat hyperthyroidism. In the current paper, we summarize the development background of these agents and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.
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