超越关节:脊柱关节病的肺动脉高压(文献综述)

S. Smiyan, Bohdan Koshak, A. Bilukha
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引用次数: 0

摘要

脊柱关节炎(SpA)是一种复杂多变的炎症性风湿病。要准确诊断和有效治疗,就必须对其临床、遗传和免疫学方面有细致入微的了解。全面的文献综述揭示了脊柱关节病与肺动脉高压(PH)之间的微妙联系,拓展了我们对关节病理学之外的这些疾病的认识。综述了各种研究的数据,为我们深入了解导致脊柱关节病患者肺动脉高压发生的各种因素之间复杂的相互作用提供了宝贵的见解。然而,由于对反应性关节炎和其他亚型的研究有限,因此有必要进一步探索,以确定整个 SpA 病谱中肺动脉高压的患病率和特征。已发现的研究空白强调了今后开展涵盖整个 SpA 病谱的研究的重要性,以便更全面地了解肺动脉高压的相关性。考虑所有致病机制至关重要,包括慢性持续性炎症、内皮功能障碍和其他相关因素的影响。认识到这些机制的重要性对于全面了解这两种病症之间复杂的相互作用、指导制定有针对性的干预措施和加强患者护理策略至关重要。这一讨论为脊柱关节病不断发展的未来研究方向和临床考虑奠定了基础。本综述为深入探讨脊柱关节病错综复杂的方方面面,包括其系统性影响和新兴治疗策略奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond Joints: Pulmonary Hypertension in Spondyloarthropathies (Literature review)
Spondyloarthritis (SpA) represents a complex and dynamic spectrum of inflammatory rheumatic diseases. A nuanced understanding of its clinical, genetic, and immunologic aspects is imperative for accurate diagnosis and effective management. The comprehensive literature review reveals a nuanced connection between spondyloarthropathies and pulmonary hypertension (PH), expanding our understanding of these conditions beyond joint pathology. The synthesis of data from various studies provides valuable insights into the complex interplay of factors contributing to the development of PH in individuals with SpA. The reviewed studies consistently indicate a heightened prevalence of elevated arterial blood pressure in the pulmonary artery among patients with ankylosing spondylitis and psoriatic arthritis. However, the limited research on reactive arthritis and other subtypes necessitates further exploration to determine the prevalence and characteristics of pulmonary hypertension across the entire spectrum of SpA. The identified gaps in research emphasize the importance of future studies that encompass the entire SpA spectrum, to provide a more complete understanding of the association with PH. It is crucial to consider all pathogenetic mechanisms, including the impact of chronic persistent inflammation, endothelial dysfunction, and other relevant factors. Recognizing the significance of these mechanisms is vital for comprehensive insights into the complex interplay between both pathologies, guiding the development of targeted interventions and enhancing patient care strategies. This discussion serves as a foundation for future research directions and clinical considerations in the evolving landscape of spondyloarthropathies. This comprehensive overview sets the stage for a deeper exploration of the intricate facets of SpA, including its systemic implications and emerging therapeutic strategies.
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