Hye-Yoom Kim , Sarah Shin , Jung-Joo Yoon , You-Mee Ahn , Ji-Hye Song , Da-Som Lee , Ji-Yeun Park , Ho-Sub Lee , Jeeyoun Jung
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引用次数: 0
摘要
背景研究电针(EA)治疗对自发性高血压大鼠(SHR)心血管功能和主动脉脂质谱的影响是本研究的基础重点。本研究的首要目标是全面阐明 EA 治疗带来的改变,并评估其作为高血压替代疗法的潜力。方法对 SHR 连续进行 EA 治疗,并评估其对收缩压、心脏功能和高血压相关神经元信号的影响。使用基于质谱的脂质分析方法分析了车辆处理的 SHR 组和 EA 处理的 SHR 组的主动脉脂质概况。结果研究表明,连续 EA 治疗可恢复 SHR 收缩压、改善心血管功能并使高血压相关神经元信号正常化。对主动脉脂质谱的分析表明,车辆治疗的 SHR 组与 EA 治疗的 SHR 组之间存在明显差异。具体来说,EA 治疗明显改变了主动脉鞘磷脂和磷脂的水平,包括超长链脂肪酰基神经酰胺和醚磷脂酰胆碱。主动脉脂质谱的这些变化与收缩压和心脏功能指标密切相关。结论 研究结果表明,EA 可能会影响 SHR 的心血管功能和主动脉脂质状况。
Exploring the potential effect of electroacupuncture on cardiovascular function and lipid profiles in spontaneously hypertensive rats
Background
Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. The overarching goal is to comprehensively elucidate the alterations brought about by EA treatment and to assess its potential as an alternative therapy for hypertension.
Methods
Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed. Aortic lipid profiles in vehicle-treated SHR and EA-treated SHR groups were analyzed using mass spectrometry-based lipid profiling. Additionally, the expression of Cers2 and GNPAT, enzymes involved in the synthesis of specific aortic lipids, was examined.
Results
The study demonstrated that consecutive EA treatments restored systolic blood pressure, improved cardiovascular function, and normalized hypertension-related neuronal signals in SHR. Analysis of the aortic lipid profiles revealed distinct differences between the vehicle-treated SHR group and the EA-treated SHR group. Specifically, EA treatment significantly altered the levels of aortic sphingomyelin and phospholipids, including very long-chain fatty acyl-ceramides and ether phosphatidylcholines. These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT.
Conclusions
The findings suggest that EA may influence cardiovascular functions and aortic lipid profiles in SHR.
期刊介绍:
Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.