Sohel M. Julovi MBBS, PhD , Katie Trinh BSc(Adv), MBBS , Harry Robertson BMedSc(Hons-I) , Cuicui Xu BSc, PhD , Nikita Minhas PhD , Seethalakshmi Viswanathan MBBS , Ellis Patrick BSc(Hons), PhD , John D. Horowitz MBBS, PhD , Daniel N. Meijles PhD , Natasha M. Rogers MBBS(Hons), PhD
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Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease
Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease. Previous studies reported that endogenous thrombospondin 1 (TSP1) involves right ventricular remodeling and dysfunction. Here we show that a murine model of CKD increased myocardial TSP1 expression and produced left ventricular hypertrophy, fibrosis, and dysfunction. TSP1 knockout mice were protected from these features. In vitro, indoxyl sulfate is driving deleterious changes in cardiomyocyte through the TSP1. In patients with CKD, TSP1 and aryl hydrocarbon receptor were both differentially expressed in the myocardium. Our findings summon large clinical studies to confirm the translational role of TSP1 in patients with CKD.
期刊介绍：
JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.
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