Catharina Gerhards , Andreas Teufel , Marlis Gerigk , Michael French , Christoph Antoni , Matthias Ebert , Michael Neumaier , Osman Evliyaoglu
{"title":"维生素 D 在病毒性肝炎患者免疫反应中的潜在作用","authors":"Catharina Gerhards , Andreas Teufel , Marlis Gerigk , Michael French , Christoph Antoni , Matthias Ebert , Michael Neumaier , Osman Evliyaoglu","doi":"10.1016/j.nut.2024.112447","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients.</p></div><div><h3>Methods</h3><p>The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data.</p></div><div><h3>Results</h3><p>In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (<em>P</em> < 0.05), but the percentage of CD8+ increased (<em>P</em> < 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (<em>P</em> < 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (<em>P</em> < 0.05 and <em>P</em> < 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (<em>P</em> < 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels.</p></div><div><h3>Conclusions</h3><p>Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. In summary, sufficient levels of Vitamin D may lead to a sustained virological response that is debatable by artificially correcting the deficiency.</p></div>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0899900724000972/pdfft?md5=0482841e597593fadc84e6c230dc6fcb&pid=1-s2.0-S0899900724000972-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Potential role of Vitamin D in immune response in patients with viral hepatitis\",\"authors\":\"Catharina Gerhards , Andreas Teufel , Marlis Gerigk , Michael French , Christoph Antoni , Matthias Ebert , Michael Neumaier , Osman Evliyaoglu\",\"doi\":\"10.1016/j.nut.2024.112447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients.</p></div><div><h3>Methods</h3><p>The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data.</p></div><div><h3>Results</h3><p>In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (<em>P</em> < 0.05), but the percentage of CD8+ increased (<em>P</em> < 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (<em>P</em> < 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (<em>P</em> < 0.05 and <em>P</em> < 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (<em>P</em> < 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels.</p></div><div><h3>Conclusions</h3><p>Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. 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引用次数: 0
摘要
背景研究慢性乙型肝炎和慢性丙型肝炎患者维生素 D 与先天性和适应性免疫反应参数的关系。 方法提取 2013 年 1 月 1 日至 2023 年 2 月 1 日期间慢性乙型肝炎（CHB）和慢性丙型肝炎（CHC）患者的实验室数据。测定了血清 25- 羟基维生素 D、乙型肝炎病毒血清学标记物、补体和 T 淋巴细胞亚群。结果与对照组相比，CHB 和 CHC 患者的 CD4+ T 淋巴细胞百分比和 CD4+/CD8+ 比率显著下降（P <0.05），但 CD8+ 的百分比上升（P <0.05）。在慢性阻塞性肺病患者中，维生素 D 的下降很明显（P < 0.001），但在慢性粒细胞白血病患者中却不明显。维生素 D 对 CHB 患者的 CD8 细胞计数有中度的负面影响。HBV DNA 和 HBsAg 的正比值随着血清维生素 D 水平的升高而降低。与正常组相比，维生素 D 缺乏组的抗体产生量明显降低，CD4 细胞数量明显减少，CD8 细胞数量明显增加（分别为 P < 0.05 和 P < 0.001），而 CD4/CD8 比值在不足组也明显降低（P < 0.001）。维生素 D 水平与补体 C3、CD8+、CD4+、CD19+ 细胞和 HBV DNA 水平显著相关。维生素 D 与补体 C3 之间的负相关关系需要阐明。此外，在维生素 D 缺乏症中，B 细胞比例的增加和 CD4+ 细胞的减少扰乱了对 HBV 的免疫反应，因为尽管 B 细胞比例增加了，却没有得到预期的抗体反应。这表明 CD4+ 细胞对 B 细胞功能有影响。总之，足够水平的维生素 D 可能会导致持续的病毒学应答，而人为地纠正维生素 D 缺乏则是值得商榷的。
Potential role of Vitamin D in immune response in patients with viral hepatitis
Background
To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients.
Methods
The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data.
Results
In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (P < 0.05), but the percentage of CD8+ increased (P < 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (P < 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (P < 0.05 and P < 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (P < 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels.
Conclusions
Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. In summary, sufficient levels of Vitamin D may lead to a sustained virological response that is debatable by artificially correcting the deficiency.
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