六类新出现污染物的致肥效应

IF 5.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Siying Wu, Chaoyu Tong, Jing Liu
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引用次数: 0

摘要

人们越来越关注暴露于环境化学品可能导致肥胖流行的概念。然而,从毒理学和环境学的角度来看,人们对新出现的污染物的致肥胖效应还没有达成共识。需要系统地讨论新出现的污染物对人类的潜在暴露和致肥胖效应的实验证据。本综述的主要目的是在对暴露于新兴污染物的人类和实验动物的文献进行批判性分析后,为后续政策的进一步制定提供建议。本文回顾了人类接触新兴污染物的情况(重点是抗菌剂、防腐剂、防水防油剂、阻燃剂、抗生素和双酚)以及新兴污染物对肥胖症的影响。这些新出现的污染物已在人体生物样本中被广泛检测到。流行病学研究提供的证据表明,接触新出现的污染物与人类肥胖的风险有关。基于动物模型和脂肪细胞的研究显示了新兴污染物的致肥胖效应,并确定了污染物可能诱发体内脂肪积累和脂质代谢平衡变化的作用模式。本文讨论了这一领域的一些知识空白和未来进一步调查的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Obesogenic effects of six classes of emerging contaminants

There is growing concern about the concept that exposure to environmental chemicals may be contributing to the obesity epidemic. However, there is no consensus on the obesogenic effects of emerging contaminants from a toxicological and environmental perspective. The potential human exposure and experimental evidence for obesogenic effects of emerging contaminants need to be systematically discussed. The main objective of this review is to provide recommendations for further subsequent policy development following a critical analysis of the literature for humans and experimental animals exposed to emerging contaminants. This article reviews human exposure to emerging contaminants (with a focus on antimicrobials, preservatives, water and oil repellents, flame retardants, antibiotics and bisphenols) and the impact of emerging contaminants on obesity. These emerging contaminants have been widely detected in human biological samples. Epidemiological studies provide evidence linking exposure to emerging contaminants to the risks of obesity in humans. Studies based on animal models and adipose cells show the obesogenic effects of emerging contaminants and identify modes of action by which contaminants may induce changes in body fat accumulation and lipid metabolic homeostasis. Some knowledge gaps in this area and future directions for further investigation are discussed.

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来源期刊
Journal of Environmental Sciences-china
Journal of Environmental Sciences-china 环境科学-环境科学
CiteScore
13.70
自引率
0.00%
发文量
6354
审稿时长
2.6 months
期刊介绍: The Journal of Environmental Sciences is an international journal started in 1989. The journal is devoted to publish original, peer-reviewed research papers on main aspects of environmental sciences, such as environmental chemistry, environmental biology, ecology, geosciences and environmental physics. Appropriate subjects include basic and applied research on atmospheric, terrestrial and aquatic environments, pollution control and abatement technology, conservation of natural resources, environmental health and toxicology. Announcements of international environmental science meetings and other recent information are also included.
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