长COVID综合征的心血管异常:致病基础以及治疗和康复的潜在策略

IF 2.3 Q2 SPORT SCIENCES
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引用次数: 0

摘要

长期冠状病毒综合征(即 2019 年冠状病毒病(COVID-19)急性后遗症)中的心脏损伤和持续性心血管异常已成为一种令人衰弱的健康负担,对从急性 COVID-19 中康复的最脆弱患者群体原有的心血管疾病和其他相关慢性合并症的管理构成了挑战。目前仍缺乏明确的循证指南来治疗长期 COVID 综合征的心脏问题。在这篇综述中,我们总结了急性 COVID-19 病后数月内报告的常见心脏症状,并进一步评估了长 COVID 病理生理过程中可能的致病因素。从机理上了解严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)如何损害心脏和血管,对于开发限制病毒发作的靶向治疗和预防措施至关重要。尽管目前已有治疗干预措施,但相当一部分从严重的 COVID-19 中康复的患者都报告说,由于身体机能下降,他们的功能储备也随之降低。因此,严格而全面的心脏康复计划以及个性化的锻炼方案将有助于长期COVID患者恢复与病前基线相当的体能水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiovascular abnormalities of long-COVID syndrome: Pathogenic basis and potential strategy for treatment and rehabilitation

Cardiac injury and sustained cardiovascular abnormalities in long-COVID syndrome, i.e. post-acute sequelae of coronavirus disease 2019 (COVID-19) have emerged as a debilitating health burden that has posed challenges for management of pre-existing cardiovascular conditions and other associated chronic comorbidities in the most vulnerable group of patients recovered from acute COVID-19. A clear and evidence-based guideline for treating cardiac issues of long-COVID syndrome is still lacking. In this review, we have summarized the common cardiac symptoms reported in the months after acute COVID-19 illness and further evaluated the possible pathogenic factors underlying the pathophysiology process of long-COVID. The mechanistic understanding of how Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) damages the heart and vasculatures is critical in developing targeted therapy and preventive measures for limiting the viral attacks. Despite the currently available therapeutic interventions, a considerable portion of patients recovered from severe COVID-19 have reported a reduced functional reserve due to deconditioning. Therefore, a rigorous and comprehensive cardiac rehabilitation program with individualized exercise protocols would be instrumental for the patients with long-COVID to regain the physical fitness levels comparable to their pre-illness baseline.

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来源期刊
Sports Medicine and Health Science
Sports Medicine and Health Science Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
5.50
自引率
0.00%
发文量
36
审稿时长
55 days
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