机械免疫检查点:调查和评估疾病与疗法的新兴战略

Q1 Engineering
Wenhui Hu , Cuifang Wu , Jinhua Long , Zhu Zeng
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引用次数: 0

摘要

过去几十年来,越来越多的证据表明,在生理和病理生理条件下,多种不同强度和模式的机械信号,包括流体流动产生的剪切应力、细胞外基质(ECM)的拓扑结构、基质的硬度、张力或压缩力,正在成为免疫反应的重要协调者。相应地,外在机械信号可能会赋予细胞独特的机械表型,再加上细胞的免疫表型,决定了最终的免疫反应类型。因此,我们提出了 "机械免疫检查点"(mechano-immunological checkpoints)的概念,它涉及免疫细胞的特征机械信号和典型机械表型,使从机械角度阐明和治疗免疫相关疾病成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechano-immunological checkpoints: An emerging strategy for investigation and evaluation of disease and therapeutics

Over the past decades, increasing evidence has indicated that multiple mechanical signals with different magnitude and pattern, including fluid flow-derived shear stress, topology of extracellular matrix (ECM), substrate stiffness, tension or compression, are now emerging as important orchestrators of immune response under physiological and pathophysiological conditions. Correspondingly, the extrinsic mechanical signals may confer the unique mechanophenotypes on cells, which coupled with their immunophenotypes, determines the ultimate type of immune response. Therefore, the concept of mechano-immunological checkpoints is proposed, which concerns the featured mechanical signals and the typical mechanophenotypes of immune cells, making it possible to elucidate and treat immune-associated disease from the mechanical viewpoint.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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