亚临床甲状腺机能减退与作为心血管风险潜在标志物的颈动脉内膜厚度之间的关系:系统回顾与元分析

O. Isailă, Victor Eduard Stoian, I. Fulga, A. Piraianu, S. Hostiuc
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引用次数: 0

摘要

背景和目的:众所周知,甲状腺功能障碍会对心血管系统产生重大影响。近年来,临床研究经常评估颈动脉内膜中层厚度(CIMT)与亚临床甲状腺功能减退症(SCH)之间的相关性。本研究旨在通过荟萃分析评估这种关联的重要性。研究方法我们以 "亚临床甲状腺功能减退症和颈动脉内膜中层厚度 "为关键词,对 PubMed、MedLine、Scopus 和 Web of Science 数据库进行了系统性检索,检索时间从每个数据库的起始时间开始,直至 2023 年 1 月。我们制定了纳入和排除标准,并考虑了符合纳入标准的研究。我们使用 Jamovi 对数据进行了统计分析。结果我们确定了 39 项符合纳入标准的观察性研究,共有 3430 名受试者:其中男性 1545 人,女性 1885 人。与甲状腺功能正常的受试者(EU)相比,亚临床甲状腺功能减退症(SCH)受试者的颈动脉内膜中层厚度(CIMT)值明显增加;估计平均差异为 0.08(95% CI 0.05 至 0.10),P < 0.01,I2 = 93.82%。经过敏感性分析后,对上述 39 项研究中的 19 项进行了分析,大多数研究显示 SCH 与颈动脉壁增厚呈正相关;估计平均差异为 0.04(95% CI 0.02 至 0.07),P = 0.03,I2 = 77.7。此外,女性性别、高龄和高胆固醇水平在统计学上对这种关联有显著影响。结论:我们的荟萃分析表明,SCH 与 CIMT 增高之间存在明显的正相关,但也存在一些局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Relationship between Subclinical Hypothyroidism and Carotid Intima-Media Thickness as a Potential Marker of Cardiovascular Risk: A Systematic Review and a Meta-Analysis
Background and Objectives: Thyroid dysfunction is known to have significant consequences on the cardiovascular system. The correlation between carotid intima-media thickness (CIMT) and subclinical hypothyroidism (SCH) has been frequently evaluated in clinical studies in recent years. This study aimed to evaluate the significance of this association through a meta-analysis. Methods: We conducted a systematic search of PubMed, MedLine, Scopus, and Web of Science databases using the keywords ‘subclinical hypothyroidism and carotid intima-media thickness’, from the beginning of each database until January 2023. We established the inclusion and exclusion criteria and considered studies that met the inclusion criteria. We used Jamovi for statistical analysis of the data. Results: We identified 39 observational studies that met the inclusion criteria, with 3430 subjects: 1545 SCH and 1885 EU. Compared to euthyroid subjects (EU), subjects with subclinical hypothyroidism (SCH) had significantly increased carotid intima-media thickness (CIMT) values; the estimated average mean difference was 0.08 (95% CI 0.05 to 0.10), p < 0.01, I2 = 93.82%. After the sensitivity analysis, a total of 19 from the 39 abovementioned studies were analyzed, with most studies showing a positive association between SCH and thickening of the carotid wall; the estimated average mean difference was 0.04 (95% CI 0.02 to 0.07), p = 0.03, I2 = 77.7. In addition, female sex, advanced age, and high cholesterol levels statistically significantly influenced this association. Conclusions: Our meta-analysis indicates a significant positive association between SCH and increased CIMT, but with some limitations.
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