绝经后动脉高血压妇女血管重塑和骨组织破坏的病因关联特征

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
Ksenia S. Avdeeva, T. I. Petelina, Elena A. Gorbatenko
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引用次数: 0

摘要

背景--非特异性免疫炎症血管反应作为一般致病机制与动脉弹性特性变化和骨骼破坏性变化现象之间的联系,其作用备受关注。目的--我们旨在研究非特异性免疫炎症标志物、甲状旁腺激素和女性性激素作为动脉高血压(AH)和骨质疏松症(OP)绝经后妇女心血管和骨骼退行性变化预测因子的作用。方法 - 我们研究了 104 名患者(平均年龄:54.03±9.56 岁),分为三组:健康女性、患有动脉高血压和骨质疏松症的女性以及患有动脉高血压和骨质疏松症的女性。我们同时分析了免疫炎症反应标记物、内皮功能障碍、激素、矿物质和维生素状况,以及 24 小时动态血压监测、血管壁僵硬度和密度测量参数,以阐明绝经后妇女心血管和骨骼退行性变化的预测因素。结果--对于AH和骨质疏松症患者,与OP风险相关的一个重要参数是脉搏波速度(PWV);脉搏波速度增加超过12.05 m/s,OP风险增加3.8倍。促炎指标、白细胞介素 IL-6 和 IL-8、肿瘤坏死因子-α、高敏 C 反应蛋白和甲状旁腺激素水平升高,而孕酮和 IL-10 水平降低。结论--及时对生化和仪器参数(脉搏波速度和骨密度测量)进行多方位的专业研究,可为制定针对妇女的个性化预防和治疗策略奠定基础,从而避免危险的心血管和骨骼并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics Of Pathogenetic Links In Vascular Remodeling And Bone Tissue Destruction In Postmenopausal Women With Arterial Hypertension
Background — Much attention is drawn to the role of the nonspecific immune inflammatory vascular response as a link of general pathogenetic mechanisms with changes in the elastic properties of arteries and the phenomena of destructive changes in bones. Objective — We aimed to study the role of nonspecific immune inflammatory markers, parathyroid hormone and female sex hormones as predictors of cardiovascular and degenerative bone changes in postmenopausal women with arterial hypertension (AH) and osteoporosis (OP). Methods — We examined 104 patients (mean age: 54.03±9.56 years) distributed among three groups: healthy women, females with AH and osteopenia, and women with AH and OP. The markers of immune inflammatory response, endothelial dysfunction, hormonal, mineral, and vitamin statuses were analyzed simultaneously with 24-hour ambulatory monitoring of blood pressure, and parameters of vascular wall stiffness and densitometry to elucidate the predictors of cardiovascular and degenerative bone changes in postmenopausal women. Results — For patients with AH and osteopenia, a significant parameter associated with the risk of OP was pulse wave velocity (PWV); its increase exceeding 12.05 m/s was associated with a 3.8-fold increase in the risk of OP. Levels of proinflammatory indicators, interleukins IL-6 and IL-8, tumor necrosis factor-α, high-sensitivity C-reactive protein, and parathyroid hormone were elevated, while levels of progesterone and IL-10 were decreased. Conclusion — Timely specialized multidirectional research of biochemical and instrumental parameters (PWV and densitometry) could become the basis for the development of a personalized strategy for the prevention and treatment of women in order to avoid dangerous cardiovascular and bone complications.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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