妊娠期和儿童期三氯生与青春期和青春期早期肾上腺结果的时变关系

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
H. Laue, B. Lanphear, A.M. Calafat, Kim M. Cecil, Aimin Chen, Yingying Xu, Heidi J. Kalkwarf, J. C. Madan, M. R. Karagas, K. Yolton, A. Fleisch, Joseph M. Braun
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引用次数: 0

摘要

三氯生是一种干扰内分泌的化学物质,但它与青春期结果的关系仍不清楚。我们研究了妊娠期和儿童期三氯生与青春期激素浓度和青春期阶段的关系。 我们对从俄亥俄州辛辛那提市招募的参与者(2003-2006 年)进行了两次孕期尿液三氯生浓度定量分析和七次出生至 12 岁期间尿液三氯生浓度定量分析。我们对整个孕期和儿童期的浓度进行了平均,并在多信息模型中分别考虑了各个暴露期。12 岁时,我们测量了血清激素浓度(男性 [n = 72],女性 [n = 84]-硫酸脱氢表雄酮,黄体生成素,卵泡刺激素;男性-睾酮;女性-雌二醇)。同样在 12 岁时,受试者还自我报告了身体发育情况和男女交配时间。我们估算了三氯生与荷尔蒙浓度、身体发育和初潮年龄的关系(95% 置信区间)。 对于女性来说,童年时期三氯生含量每增加一倍,雌二醇浓度就会降低 16%(-29%,0%),更接近青春期的测量值关联性更强。我们发现,有提示性证据表明,在任何年龄段,三氯生含量越高,男性的卵泡刺激素浓度就会降低约 10%(妊娠期三氯生:-18%,-2%),而产后早期(1-3 岁)三氯生含量越高,女性阴毛提前发育的几率就会降低 63%(5%,96%)。在多信息模型中,妊娠期三氯生浓度每增加一倍,月经初潮年龄提前 5%(0%,9%),相当于提前 5.5 个月。 妊娠期和儿童期的三氯生浓度与一些青春期结果有关,包括激素浓度和初潮年龄。我们的研究结果突显了阐明三氯生潜在的性别特异性和时间依赖性作用的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence
Triclosan is an endocrine-disrupting chemical, but associations with pubertal outcomes remain unclear. We examined associations of gestational and childhood triclosan with adolescent hormone concentrations and pubertal stage. We quantified urinary triclosan concentrations twice during pregnancy and seven times between birth and 12 years in participants recruited from Cincinnati, OH (2003–2006). We averaged concentrations across pregnancy and childhood and separately considered individual exposure periods in multiple informant models. At 12 years, we measured serum hormone concentrations (males [n = 72] and females [n = 84]—dehydroepiandrosterone-sulfate, luteinizing hormone, follicle-stimulating hormone; males—testosterone; females—estradiol). Also at age 12 years, participants self-reported physical development and menarchal timing. We estimated associations (95% confidence interval) of triclosan with hormone concentrations, more advanced physical development, and age at menarche. For females, each doubling of childhood triclosan was associated with 16% lower estradiol concentrations (−29%, 0%), with stronger associations for measures closer to adolescence. We found suggestive evidence that higher triclosan at any age was associated with ~10% (for gestational triclosan: −18%, −2%) lower follicle-stimulating hormone concentrations among males and early postnatal (1–3 years) triclosan was associated with 63% (5%, 96%) lower odds of advanced pubic hair development in females. In multiple informant models, each doubling of gestational triclosan concentrations was associated with 5% (0%, 9%) earlier age at menarche, equivalent to 5.5 months. Gestational and childhood triclosan concentrations were related to some pubertal outcomes including hormone concentrations and age at menarche. Our findings highlight the relevance of elucidating potential sex-specific and time-dependent actions of triclosan.
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来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
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