白藜芦醇促进自我消化,让癌症安睡

IF 2.5 Q3 ONCOLOGY
Alessandra Ferraresi, Suyanee Thongchot, C. Isidoro
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引用次数: 0

摘要

白藜芦醇是一种存在于多种食品中的天然多酚,已在多个体外和体内模型中被证明具有预防和治疗癌症的活性。这种化学预防/抗癌活性与涉及致癌和转移的多种途径的生化和表观遗传学改变有关。在这篇评论中,我们将重点介绍我们实验室最近完成的一项工作,该工作表明白藜芦醇具有预防和治疗癌症的潜力,它能促进表观遗传学介导的自噬依赖性肿瘤休眠,这种效应与癌症相关成纤维细胞的再教育和肿瘤微环境中炎症细胞因子的产生减少有关。此外,还讨论了白藜芦醇抗癌活性现有知识的临床转化问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resveratrol Promotes Self-digestion to Put Cancer to Sleep
Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment. The clinical translation of the current knowledge on resveratrol anticancer activity is also discussed.
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