{"title":"不同温度下苯磺酸氨氯地平在丙二醇和乙醇混合物中的溶解度研究","authors":"Homa Rezaei, Nastaran Hashemzadeh, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban","doi":"10.1007/s10953-024-01373-9","DOIUrl":null,"url":null,"abstract":"<div><p>In this research, the solubility of amlodipine besylate was studied in the propylene glycol + ethanol mixtures at different temperatures (293.2–313.2 K). The study showed that the solubility increases with an increase in propylene glycol concentration, reaching its highest point at <i>w</i><sub>1</sub> = 0.8. Additionally, the solubility values have a positive correlation with temperature, which is typical for the solid solutes. The experimental solubility data were correlated with some well known cosolvency models and the accuracy of these models was investigated with the mean relative deviations (<i>MRDs</i>%) of the back-calculated data. <i>MRDs</i> were 1.2% for the van’t Hoff model, 4.3 and 4.6% for the Jouyban–Acree and Jouyban–Acree–van’t Hoff equations, 1.4% for the MRS model and 2.1% for the modified Wilson model. The apparent thermodynamic parameters (standard state Gibbs energy, enthalpy, and entropy) of dissolution of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at <i>T</i><sub>hm</sub> = 303.0 K.</p></div>","PeriodicalId":666,"journal":{"name":"Journal of Solution Chemistry","volume":"53 9","pages":"1234 - 1245"},"PeriodicalIF":1.4000,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solubility Studies of Amlodipine Besylate in Propylene Glycol + Ethanol Mixtures at Different Temperatures\",\"authors\":\"Homa Rezaei, Nastaran Hashemzadeh, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban\",\"doi\":\"10.1007/s10953-024-01373-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this research, the solubility of amlodipine besylate was studied in the propylene glycol + ethanol mixtures at different temperatures (293.2–313.2 K). The study showed that the solubility increases with an increase in propylene glycol concentration, reaching its highest point at <i>w</i><sub>1</sub> = 0.8. Additionally, the solubility values have a positive correlation with temperature, which is typical for the solid solutes. The experimental solubility data were correlated with some well known cosolvency models and the accuracy of these models was investigated with the mean relative deviations (<i>MRDs</i>%) of the back-calculated data. <i>MRDs</i> were 1.2% for the van’t Hoff model, 4.3 and 4.6% for the Jouyban–Acree and Jouyban–Acree–van’t Hoff equations, 1.4% for the MRS model and 2.1% for the modified Wilson model. The apparent thermodynamic parameters (standard state Gibbs energy, enthalpy, and entropy) of dissolution of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at <i>T</i><sub>hm</sub> = 303.0 K.</p></div>\",\"PeriodicalId\":666,\"journal\":{\"name\":\"Journal of Solution Chemistry\",\"volume\":\"53 9\",\"pages\":\"1234 - 1245\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Solution Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10953-024-01373-9\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Solution Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10953-024-01373-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Solubility Studies of Amlodipine Besylate in Propylene Glycol + Ethanol Mixtures at Different Temperatures
In this research, the solubility of amlodipine besylate was studied in the propylene glycol + ethanol mixtures at different temperatures (293.2–313.2 K). The study showed that the solubility increases with an increase in propylene glycol concentration, reaching its highest point at w1 = 0.8. Additionally, the solubility values have a positive correlation with temperature, which is typical for the solid solutes. The experimental solubility data were correlated with some well known cosolvency models and the accuracy of these models was investigated with the mean relative deviations (MRDs%) of the back-calculated data. MRDs were 1.2% for the van’t Hoff model, 4.3 and 4.6% for the Jouyban–Acree and Jouyban–Acree–van’t Hoff equations, 1.4% for the MRS model and 2.1% for the modified Wilson model. The apparent thermodynamic parameters (standard state Gibbs energy, enthalpy, and entropy) of dissolution of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at Thm = 303.0 K.
期刊介绍：
Journal of Solution Chemistry offers a forum for research on the physical chemistry of liquid solutions in such fields as physical chemistry, chemical physics, molecular biology, statistical mechanics, biochemistry, and biophysics. The emphasis is on papers in which the solvent plays a dominant rather than incidental role. Featured topics include experimental investigations of the dielectric, spectroscopic, thermodynamic, transport, or relaxation properties of both electrolytes and nonelectrolytes in liquid solutions.
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