取代型 4-氨基-3,5-双(2,4-二氯苯氧基)-1,2,4-三唑的合成、表征和生物活性研究

Omar Yahya
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引用次数: 0

摘要

在本文中,酯(2)是通过 2,4-二氯苯氧基乙酸与甲醇反应制备的,在该反应中使用浓硫酸作为催化剂,当与水合肼反应时,得到酸肼。(3) 在溶剂温度下,用二甲亚砜进行回流,得到 4-氨基-3,5-双-(2,4-二氯苯氧基)-1,2,4-三唑化合物 (4)。通过与不同的苯甲醛替代物反应,得到了 4-氨基-3,5-双-(2,4-二氯苯氧基)-1,2,4-三唑(4)。通过薄层色谱法(TLC)确认了所有制备化合物的完整性和纯度,并显示了一些物理和光谱特性,即(傅立叶变换红外光谱 1H-NMR 和 13C-NMR)。此外,还研究了所制备化合物的生物活性,并讨论了它们对不同类型细菌(如芽孢杆菌、大肠杆菌和金黄色葡萄球菌)的有效性。利用圆盘扩散技术对真菌和细菌进行的研究表明,这些化合物对上述菌种具有良好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, Characterization and Study Biological Activity of Substituted 4-Amino -3,5-Bis (2,4-dichloro phenoxy)-1,2,4-Triazole
In this paper, the ester (2) was prepared by reacting 2,4-dichlorophenoxy acetic acid with methyl alcohol and using concentrated sulfuric acid as a catalyst in this reaction, which, when reacted with hydrazine hydrate, obtained acid hydrazide. (3), under reflux conditions with dimethyl sulfoxide and at solvent temperature, the compound 4-amino-3,5-bis-(2,4-dichlorophenoxy)-1,2,4-triazole was obtained (4). It was obtained and used to prepare a series of new Schiff bases (5a-e) through their reaction with different substitutes of benzaldehyde. The completeness and purity of all the prepared compounds were confirmed by thin-layer chromatography (TLC) and showed some physical and spectroscopic properties, namely (FT -IR 1H-NMR and 13C-NMR). In addition, the biological activity of the prepared compounds was studied, and their effectiveness against different types of bacteria such as Bacillus, Escherichia coli , and Staphylococcus aureus was discussed. Studies of mainly fungi and bacteria have shown good efficacy against the mentioned species using disc diffusion technology.
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