用于临床应用的钛表面钴、锶和氟共掺氧化物薄膜的制备、表征和生物活性

IF 2.9 4区 医学 Q1 Medicine
Xinglin Wu, Yang Jiao, Jieshi Wu, Sujiajun Zhang, Ruisheng Xu, Quanming Zhao, K. Lu, Pengpeng Zhang, Lu Zhang, Xiaohui Ni
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引用次数: 0

摘要

钛和钛合金因其优异的综合机械性能、耐腐蚀性和生物相容性而受到广泛关注。然而,钛金属本身在生理环境中具有生物惰性,植入人体后被一层包裹性纤维膜包围,很难与组织形成牢固的结合。等离子电解氧化是一种在钛和钛合金表面制备生物活性多孔陶瓷膜的新技术。它在钛合金的仿生物表面改性方面具有应用前景。本研究通过等离子电解氧化法在钛表面制备了钴锶氟共掺氧化物薄膜(TAM-CSF)。利用场发射扫描电子显微镜、能谱分析、原子力显微镜、轮廓仪和 X 射线光电子能谱对薄膜的表面特性进行了评估。此外,还利用电化学工作站对材料的腐蚀性能进行了评估。体外细胞实验测试了薄膜的生物相容性和生物活性。结果表明,钛表面的 TAM-CSF 呈多孔状,CSF 均匀地掺杂在薄膜表面。TAM-CSF 改善了钛的表面粗糙度。这种薄膜具有良好的生物相容性,能促进 MC3T3-E1 细胞的扩展和增殖。通过等离子电解氧化法可以在钛表面制备 TAM-CSF。该薄膜具有良好的形态和生物活性,具有临床应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preparation, Characterization, and Bioactivities of Cobalt, Strontium and Fluorine Co-Doped Oxide Films on Titanium Surface for Clinical Application
Titanium and titanium alloys are receiving widespread attention due to their excellent comprehensive mechanical properties, corrosion resistances, and biocompatibilities. However, titanium metal itself is biologically inert in physiological environments, and after implantation, it is surrounded by a layer of encapsulating fibrous membrane, making it difficult to form solid bonds with the tissue. Plasma electrolytic oxidation is a new technology used to prepare bioactive porous ceramic membranes on the surfaces of titanium and titanium alloys. It has application prospects for biomimetic surface modifications of titanium alloys. In this study, a cobalt, strontium and fluorine codoped oxide film (TAM-CSF) was prepared on a titanium surface via plasma electrolytic oxidation. The surface characteristics of the film were evaluated with field emission scanning electron microscopy, energy spectrum analyses, atomic force microscopy, profilometry and X-ray photoelectron spectroscopy. Additionally, the corrosion performance of the material was evaluated with an electrochemical workstation. The biocompatibility and bioactivity of the film were tested with in vitro cell experiments. The results showed that the TAM-CSF on the titanium surface had a porous morphology, and the CSF was uniformly doped on the film surface. TAM-CSF improved the surface roughness of the titanium. This film exhibited good biocompatibility and promoted the extension and proliferation of MC3T3-E1 cells. It was possible to prepare TAM-CSF on titanium surfaces via plasma electrolytic oxidation. The film exhibited a good morphology and good biological activity and has clinical application prospects.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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