姜黄素包裹的玉米蛋白/多糖纳米颗粒对疲劳应激损伤的影响

IF 2.9 4区 医学 Q1 Medicine
Qin Liu
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引用次数: 0

摘要

在这项研究中,我们制备了芯壳纳米粒子作为姜黄素(Cur)的给药系统。该纳米颗粒由 Zein 和两种多糖组成,即阿拉伯树胶(GA)和亚麻籽胶(FG)。此外,我们还利用动物疲劳应激模型研究了Cur负载纳米颗粒对疲劳应激损伤的影响。此外,我们还设计了一种微针贴片,以增强这些纳米颗粒的输送和持续释放。结果表明,与模型组相比,所有治疗组都明显延长了游泳和跑步的耗竭时间(P < 0.001),其中高剂量治疗组的跑步时间最长。此外,我们的研究结果表明,与游离的 Cur 和与空白纳米颗粒混合的 Cur 相比,负载 Cur 的纳米颗粒具有更优越的抗疲劳应力激活特性。此外,通过增强药物对皮肤角质层的渗透,我们的微针载体大大提高了给药效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Curcumin-Loaded Zein/Polysaccharides Nanoparticles on Fatigue Stress Injury
In this study, we prepare core–shell nanoparticles as a delivery system for curcumin (Cur). The nanoparticles are composed of Zein and two polysaccharides, namely gum arabic (GA) and flaxseed gum (FG). Furthermore, we investigate the effect of Cur-loaded nanoparticles on fatigue stress injury using an animal fatigue stress model. Furthermore, we design a microneedle patch to enhance the delivery and sustained release of these nanoparticles. The results demonstrated that compared to the model group, all treatment groups exhibited significantly prolonged exhausted swimming and running times (P < 0.001), with the high-dose treatment group showing the longest running time. Moreover, our findings revealed that Cur-loaded nanoparticles possessed superior anti-fatigue stress activation properties compared to free Cur and Cur mixed with blank nanoparticles. Additionally, by enhancing drug penetration into the stratum corneum of the skin, our microneedle carrier greatly improved drug delivery efficiency.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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