{"title":"外泌体治疗女性生殖衰老","authors":"Mengtong Zhang , Sichen Zhang , Shaowei Wang","doi":"10.1016/j.vesic.2024.100036","DOIUrl":null,"url":null,"abstract":"<div><p>As life expectancy continues to extend, the adverse effects of reproductive aging on female health have become progressively conspicuous. Despite the extant focus on symptom alleviation, a paucity of pharmaceutical interventions addresses the underlying causative factors. Exosome therapy, acknowledged for its relatively safe cell-free approach, emerges as a promising avenue. Notably, exosomes derived from stem cells exhibit comparable efficacy to their cellular counterparts. Nevertheless, extant methodologies for exosome production exhibit several limitations, particularly in achieving high-caliber, large-scale manufacturing. Consequently, this review is dedicated to elucidating the ongoing research endeavors and advancements of exosome therapy pertaining to the female reproductive aging.</p></div>","PeriodicalId":73007,"journal":{"name":"Extracellular vesicle","volume":"3 ","pages":"Article 100036"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773041724000039/pdfft?md5=11eddf30d49e0634cf714c1960cb80f4&pid=1-s2.0-S2773041724000039-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exosome therapy in female reproductive aging\",\"authors\":\"Mengtong Zhang , Sichen Zhang , Shaowei Wang\",\"doi\":\"10.1016/j.vesic.2024.100036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>As life expectancy continues to extend, the adverse effects of reproductive aging on female health have become progressively conspicuous. Despite the extant focus on symptom alleviation, a paucity of pharmaceutical interventions addresses the underlying causative factors. Exosome therapy, acknowledged for its relatively safe cell-free approach, emerges as a promising avenue. Notably, exosomes derived from stem cells exhibit comparable efficacy to their cellular counterparts. Nevertheless, extant methodologies for exosome production exhibit several limitations, particularly in achieving high-caliber, large-scale manufacturing. Consequently, this review is dedicated to elucidating the ongoing research endeavors and advancements of exosome therapy pertaining to the female reproductive aging.</p></div>\",\"PeriodicalId\":73007,\"journal\":{\"name\":\"Extracellular vesicle\",\"volume\":\"3 \",\"pages\":\"Article 100036\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2773041724000039/pdfft?md5=11eddf30d49e0634cf714c1960cb80f4&pid=1-s2.0-S2773041724000039-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Extracellular vesicle\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2773041724000039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Extracellular vesicle","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773041724000039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
As life expectancy continues to extend, the adverse effects of reproductive aging on female health have become progressively conspicuous. Despite the extant focus on symptom alleviation, a paucity of pharmaceutical interventions addresses the underlying causative factors. Exosome therapy, acknowledged for its relatively safe cell-free approach, emerges as a promising avenue. Notably, exosomes derived from stem cells exhibit comparable efficacy to their cellular counterparts. Nevertheless, extant methodologies for exosome production exhibit several limitations, particularly in achieving high-caliber, large-scale manufacturing. Consequently, this review is dedicated to elucidating the ongoing research endeavors and advancements of exosome therapy pertaining to the female reproductive aging.
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