Joseph P Nkolola, Jinyan Liu, Ai-ris Y Collier, Catherine Jacob-Dolan, Yasmeen Senussi, Ella Borberg, Zoe Swank, David R Walt, Dan H Barouch
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引用次数: 0
摘要
SARS-CoV-2 之前的感染情况通常是通过核壳血清学检测法来衡量的。在本研究中,我们发现在检测核壳特异性免疫反应方面,Simoa 血清学检测和 T 细胞胞内细胞因子染色检测比临床 Elecsys 检测更灵敏。这些数据表明,人群中 SARS-CoV-2 既往感染率可能高于目前的认识。
High Frequency of Prior SARS-CoV-2 Infection by Sensitive Nucleocapsid Assays
Prior infection with SARS-CoV-2 is typically measured by nucleocapsid serology assays. In this study, we show that the Simoa serology assays and T cell intracellular cytokine staining assays are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated.