一种罕见的基因变异会使母体减数分裂重组偏向于妊娠失败的风险

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-04-03 DOI:10.1038/s41594-024-01269-8

Sara A. Carioscia, Rajiv C. McCoy

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引用次数: 0

摘要

妊娠失败在人类中很常见，但调节其发生率的母体遗传因素在很大程度上还不为人所知。在一项全基因组关联研究的荟萃分析中，研究人员发现了一种基因变异，这种变异似乎会在卵子形成过程中调节同源染色体间的减数分裂重组，从而增加妊娠失败的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

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A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss

Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.