在 Pd/NHC 催化下通过呋喃核的分子内 C(3)-H 芳基化合成呋喃并[2,3-c]喹啉酮

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-03-01 DOI:10.1016/j.mencom.2024.02.012

Konstantin E. Shepelenko , Irina G. Gnatiuk , Mikhail E. Minyaev , Victor M. Chernyshev

引用次数: 0

摘要

从 2-糠酸 N-（邻溴芳基）-酰胺通过呋喃核的选择性分子内 C(3)-H 芳基化反应制备呋喃并[2,3-c]喹啉-4(5H)-酮的高效程序包括由 Pd(OAc)2 和易得的 IPrSPh HCl 原配体原位生成的 Pd/NHC 系统催化。制备出了一系列新型呋喃并[2,3-c]喹啉-4(5H)-酮，分离产率为 65-80%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis

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Synthesis of furo[2,3-c]quinolinones via intramolecular C(3)–H arylation of furan core under Pd/NHC-catalysis

An efficient procedure for the preparation of furo[2,3-c]-quinolin-4(5H)-ones from 2-furoic acid N-(o-bromoaryl)- amides via selective intramolecular C(3)–H arylation of the furan nucleus involves the catalysis by a Pd/NHC system generated in situ from Pd(OAc)₂ and readily available IPr^SPh HCl proligand. A series of novel furo[2,3-c]quinolin-4(5H)-ones were prepared in 65–80% isolated yields.

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.