含有一氧化氮供体药物的果胶纳米颗粒:组织再生的潜在方法

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Noha I. Elsherif , Abdulaziz M. Al-Mahallawi , Iman Saad Ahmed , Rehab N. Shamma
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引用次数: 0

摘要

伤口愈合和组织再生过程涉及多个关键机制,以确保产生具有类似细胞功能的新组织。本研究探讨了天然多糖果胶和一氧化氮(NO)供体药物盐酸奈必洛尔(NBV)对伤口愈合的影响。利用离子凝胶技术,采用 2231 全因子设计开发出了负载 NBV 的果胶纳米颗粒。使用 Design expert® 软件确定的优化配方的封装效率为 70.68%,zeta 电位为 -51.4 mV,粒径为 572 nm,具有球形、离散形态的特点。研究人员进行了一项体内研究,以评估最佳配方与各种对照组相比在伤口愈合方面的效果。结果表明,最佳配方具有更强的加速伤口愈合能力。此外,组织病理学检查进一步证实了该配方对受伤后 15 天伤口处组织增殖和胶原沉积的益处。这表明,所开发的配方不仅能促进伤口快速愈合,而且副作用极小,因此有望成为一种有效促进伤口愈合和组织再生的制剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration

Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration

The process of wound healing and tissue regeneration involves several key mechanisms to ensure the production of new tissues with similar cellular functions. This study investigates the impact of pectin, a natural polysaccharide, and nebivolol hydrochloride (NBV), a nitric oxide (NO) donor drug, on wound healing. Utilizing ionotropic gelation, NBV-loaded pectin nanoparticles were developed following a 2231 full factorial design. The optimized formulation, determined using Design expert® software, exhibited an encapsulation efficiency percentage of 70.68%, zeta potential of −51.4 mV, and a particle size of 572 nm, characterized by a spherical, discrete morphology. An in vivo study was conducted to evaluate the effectiveness of the optimal formulation in wound healing compared to various controls. The results demonstrated the enhanced ability of the optimal formulation to accelerate wound healing. Moreover, histopathological examination further confirmed the formulation's benefits in tissue proliferation and collagen deposition at the wound site 15 days post-injury. This suggests that the developed formulation not only promotes faster healing but does so with minimal side effects, positioning it as a promising agent for effective wound healing and tissue regeneration.

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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
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