骨骼对机械应力的感知和反应

IF 13.7 1区 生物学 Q1 BIOLOGY
Sicheng Ding , Yiren Chen , Chengshuo Huang , Lijun Song , Zhen Liang , Bo Wei
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引用次数: 0

摘要

在骨骼的生长、发育、形态塑造和维持等复杂过程中,机械应力是一个基本因素。应力在塑造骨骼框架方面的深远影响促使人们断言,应力本质上孕育了骨骼。尽管如此,骨骼感知和响应机械应力的机制仍然是个谜。在这篇综合性综述中,我们的研究重点是硬骨素的结构组成和特征,从而推断硬骨素是骨骼中负责承受和感知机械应力的主要结构。此外,我们还提出,硬骨内的骨细胞是主要的机械敏感细胞,能敏锐地感知机械应力。我们还详细分析了机械应力从细胞外基质传递到细胞核的可能途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perception and response of skeleton to mechanical stress

Mechanical stress stands as a fundamental factor in the intricate processes governing the growth, development, morphological shaping, and maintenance of skeletal mass. The profound influence of stress in shaping the skeletal framework prompts the assertion that stress essentially births the skeleton. Despite this acknowledgment, the mechanisms by which the skeleton perceives and responds to mechanical stress remain enigmatic. In this comprehensive review, our scrutiny focuses on the structural composition and characteristics of sclerotin, leading us to posit that it serves as the primary structure within the skeleton responsible for bearing and perceiving mechanical stress. Furthermore, we propose that osteocytes within the sclerotin emerge as the principal mechanical-sensitive cells, finely attuned to perceive mechanical stress. And a detailed analysis was conducted on the possible transmission pathways of mechanical stress from the extracellular matrix to the nucleus.

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来源期刊
Physics of Life Reviews
Physics of Life Reviews 生物-生物物理
CiteScore
20.30
自引率
14.50%
发文量
52
审稿时长
8 days
期刊介绍: Physics of Life Reviews, published quarterly, is an international journal dedicated to review articles on the physics of living systems, complex phenomena in biological systems, and related fields including artificial life, robotics, mathematical bio-semiotics, and artificial intelligent systems. Serving as a unifying force across disciplines, the journal explores living systems comprehensively—from molecules to populations, genetics to mind, and artificial systems modeling these phenomena. Inviting reviews from actively engaged researchers, the journal seeks broad, critical, and accessible contributions that address recent progress and sometimes controversial accounts in the field.
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