M M Emran, N R Roy, M A Hoque, H Rahaman, G K Paul, N Fatema
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引用次数: 0
摘要
帕金森病是一种令人衰弱的神经退行性疾病,目前尚无根治方法。它的特征是运动迟缓、静止性震颤、僵直和姿势不稳,这是由于参与协调身体运动的基底神经节功能受损所致。神经炎症是早期帕金森病的发病机制。高敏 C 反应蛋白水平是一种有用的非特异性炎症生化标志物。本研究旨在分析帕金森病的症状及其与高敏C反应蛋白的相关性。2014年9月至2016年3月,孟加拉国班加班杜-谢赫-穆吉布医科大学(BSMMU)神经病学系对76名帕金森病患者进行了横断面观察研究。研究分析了这些患者的帕金森病症状及其与高敏 CRP 的相关性。这项研究针对 76 名早期出现症状的帕金森病患者。震颤持续时间与高灵敏度 CRP 之间存在高度显著的正相关关系(r=0.430,p
Symptom Analysis of Early Parkinson's Disease and its Correlation with High Sensitivity C-reactive Protein.
Parkinson's disease is a debilitating neurodegenerative disease for which there is no cure. It is characterized by bradykinesia, resting tremor, rigidity and postural instability, due to impairment of function of the basal ganglia which is involved in the coordination of body movement. Neuro-inflammation is pathogenesis of development in early Parkinson's disease. High-sensitivity C-reactive protein level is a useful non-specific biochemical marker of inflammation. Objective of this study was to analyze the symptoms of Parkinson disease and it's correlation with high sensitive CRP. Seventy-six Parkinson's disease patients were enrolled in this Cross-sectional observational study that was attended in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh from September 2014 to March 2016. Analysis of the symptoms of Parkinson disease and it's correlation with high sensitive CRP were done among these patients. This study was performed on 76 Parkinson disease patients with presented early with symptoms. a positive and highly significant correlation were seen in between duration of tremor and High sensitivity CRP (r=0.430, p<0.001) and between duration of bradykinesia and High sensitivity CRP (r=0.426, p<0.001) which indicate increase duration causes increase level of high-sensitivity C-reactive protein value. The neuro-inflammation plays a significant role in the pathogenesis of symptoms development in early Parkinson's disease.